Extracellular matrix and cardiovascular diseases.

Extracellular matrix and cardiovascular diseases. Research Abstract Details 

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Extracellular matrix and cardiovascular diseases. Abstract Text:

H Ju,I M Dixon,

Extracellular matrix (ECM) in the heart and vascular wall includes fibrous proteins and proteoglycans. Fibrous proteins are classified within two categories: structural (collagen and elastin) and adhesive molecules (laminin and fibronectin). These ECM components are important in maintenance of both structure and function of the heart and vascular tissues. Myocardial infarction, hypertrophy, hypertension and heart failure are well known to be associated with progressive cardiac fibrosis. Vascular hypertrophy and thickening has been associated with the pathological series of events that attends both hypertension and restenosis. The accumulation of ECM in the cardiovascular system plays an important role in the development of heart failure after myocardial infarction and hypertension, as well as in vascular hypertrophy and restenosis. Angiotensin II (angiotensin) and transforming growth factor beta 1 are known to play a role in signalling the abnormal accumulation of ECM in these cardiovascular diseases. Administration of angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 antagonist is associated with regression of cardiac hypertrophy and fibrosis as well as vascular hypertrophy.

Extracellular matrix and cardiovascular diseases. Publishing Authors By Initials

H Ju,IM Dixon,

For similar carbohydrates: polysaccharides: proteoglycans research abstracts see: carbohydrates: polysaccharides: proteoglycans research

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Extracellular matrix and cardiovascular diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: The Canadian journal of cardiology

VOLUME: 12

Page Numbers: 1259-67

Journal Abbreviation:

ISSN: 1916-7075

DAY: 3

MONTH: Dec

YEAR: 1996

Extracellular matrix and cardiovascular diseases. Information

Number of References: 78

LANGUAGE: eng

NlmUniqueID: 8510280

Extracellular matrix and cardiovascular diseases. Keywords Mesh Terms:

KEYWORDS: Proteoglycans

MESH TERMS: metabolism

Chemical & Substance for Abstract: Extracellular matrix and cardiovascular diseases. Information

Substance Name: Angiotensin I

Registry Number: 9041-90-1

Grant and Affiliation Information for Extracellular matrix and cardiovascular diseases.

AFFILIATION: Molecular Cardiology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg.

Country: CANADA

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MEDLINETA: Can J Cardiol

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