Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Abstract Text:

Alcohol dependence is one of the leading causes of morbidity and mortality in Native Americans. Externalizing disorders such as conduct disorder (CD) and antisocial personality disorder (ASPD) have been demonstrated to have significant comorbidity with alcohol dependence in the general population. This study's aims were to: assess the comorbidity of DSM-III-R ASPD and CD with alcohol dependence, to map susceptibility loci for ASPD and CD, and to see if there is overlap with loci previously mapped for alcohol dependence phenotypes in 587 American Indians. Alcohol dependence was found to be comorbid with DSM-III-R ASPD but not CD. However, the amount of alcohol dependence in the population attributable to ASPD and/or CD is low. ASPD and the combined phenotype of participants with ASPD or CD were both found to have significant heritability, whereas no significant evidence was found for CD alone. Genotypes were determined for a panel of 791 micro-satellite polymorphisms in 251 of the participants. Analyses of multipoint variance component LOD scores, for ASPD and ASPD/CD, revealed six locations that had a LOD score of 2.0 or above: on chromosome 13 for ASPD and on chromosomes 1, 3, 4, 14, 17, and 20 for ASPD/CD. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies for externalizing diagnoses. These results also further identify new regions of the genome, that do not overlap with alcohol dependence phenotypes previously identified in this population, that may be unique to either the phenotypes evaluated or this population of American Indians.

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 147B

Page Numbers: 690-8

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-485X

DAY: 5

MONTH: Sep

YEAR: 2008

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235742

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.

AFFILIATION: Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA. cindye@scripps.edu

Country: United States

AGENCY: United States NIDA

GRANT: DA019333

ACRONYM: DA

MEDLINETA: Am J Med Genet B Neuropsychiat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis Related Publications

• A monitor for neutron flux measurements up to 20 MeV.
• Age at first intoxication and alcohol use disorders in Southwest California Indians.
• Anaerobic infections in clinical medicine. A microbiological and clinical introduction.
• Association Between Single Nucleotide Polymorphisms in the Cannabinoid Receptor Gene (CNR1) and Impulsivity in Southwest California Indians.
• Association between fibrinogen and other risk factors for cardiovascular disease in men and women. Results from the Göteborg MONICA survey 1985.
• Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.
• Beta-blockers and plasma triglycerides.
• Closing volume in 50- and 60- year old men: (a preliminary report).
• Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.
• Genomic screen for loci associated with alcohol dependence in Mission Indians.
• Genomic screen for substance dependence and body mass index in southwest California Indians.
• Impediments to the control of hypertension. Hypertension Management Audit Group.
• Nitrogen closing volume-test in 50- and 60- year-old men.
• Normative data for commercial pineapple juice from concentrate.
• Postoperative pain.
• Prevalence of primary and secondary hypertension: studies in a random population sample.
• Quality of life and Helicobacter pylori eradication.
• Quality of life in upper gastrointestinal disorders.
• Rapidly progressive autosomal dominant Parkinsonism and dementia with Pallido-Ponto-Nigral Gegeneration (PPND) and Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex (DDPAC) are clinically distinct conditions that are both linked to 17q21-22.
• Synergistic effects of risk factors.
• [Cancer of the rectum as labor complication.]
• [Disease anxiety among medical students and law students]
• [Hypochondriasis and cognitive therapy]
• [IRON CONTENT IN RED WINE ETC.]
• [Interferons. Biological principal and practical application]
• [Psychomotor physical therapy--patients' starting point and their evaluation of the therapeutic results]
• [Psychotherapeutic counselling via telecommunication networks]
• [Rupture of the uterus; case report.]