Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer.

Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer. Research Abstract Details 

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Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer. Abstract Text:

W B Growdon,E Lopez-Varela,R Littell,E Oliva,M Seiden,C Krasner,H Lee,A Fuller,

Central nervous system metastasis from gynecological malignancy is a rare phenomenon that has been described in the past 30 years. The objective of this study is to analyze the treatment modalities and prognostic factors for brain metastases from gynecological tumors that predict prolonged survival. A retrospective chart and pathology review of 47 patients diagnosed with a gynecological tumor with brain metastasis in 1994-2004 was performed. Thirty patients had undergone initial diagnosis and treatment at our institution, and 17 patients were referred following primary treatment at an outside institution. Adjusted Chi-square, Kaplan-Meier survival estimates, log-rank tests, and Cox regression analysis were utilized for statistical analysis of the total cohort. Of the 3146 patients with newly diagnosed gynecological cancer in this 10-year period, 30 developed brain metastasis demonstrating an incidence of 0.95%. Overall median survival from the time of diagnosis of brain metastasis was 7.5 months (95% CI 4-15, range 9 days-64 months) and 40% survival at 1 year. Multivariate analysis revealed evidence of extracranial disease at time of metastasis diagnosis predicted decreased survival (hazard ratio 6.207), while papillary serous histology (hazard ratio 0.42), and use of any chemotherapy (hazard ratio 0.24) predicted longer survival. No other patient or tumor characteristics were found to be independent prognostic indicators affecting survival. Despite the ominous prognosis associated with the development of brain metastasis, these retrospective data suggest that multimodal therapy with whole brain radiation therapy, chemotherapy, and surgical resection of metastases in selected patients without evidence of extracranial and with solitary or multiple lesions can prolong survival.

Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer. Publishing Authors By Initials

WB Growdon,E Lopez-Varela,R Littell,E Oliva,M Seiden,C Krasner,H Lee,A Fuller,

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PUBMED ID PMID:

MEDLINE DATE: 2008 Mar-Apr

Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of gynecological cancer : of

VOLUME: 18

Page Numbers: 262-8

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ISSN: 1525-1438

DAY: 22

MONTH: 06

YEAR: 2007

Extent of extracranial disease is a powerful predictor of survival in patients with brain metastases from gynecological cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9111626

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AFFILIATION: Division of Gynecology Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, USA.

Country: United States

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MEDLINETA: Int J Gynecol Cancer

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