Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation.

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Research Abstract Details 

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Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Abstract Text:

M Ray,S Dharmarajan,J Freudenberg,W Zhang,G A Patterson,

Lung transplantation is the treatment of choice for end-stage pulmonary diseases. A limited donor supply has resulted in 4,000 patients on the waiting list. Currently, 10-20% of donor organs offered for transplantation are deemed suitable under the selection criteria, of which 15-25% fail due to primary graft dysfunction (PGD). This has spawned efforts to re-examine the current selection criteria as well as search for alternative donor lungs selection criteria. In this study, we attempt to further our understanding of PGD by observing the changes in gene expression across donor lungs that developed PGD versus those that did not. From our analysis, we have obtained differentially expressed transcripts that were involved in signaling, apoptosis and stress-activated pathways. Results also indicate that metallothionein 3 was over expressed in lungs that didn't develop PGD. This is the first such attempt to perform expression profiling of actual human lungs used for transplantation, for the identification of a molecular signature for PGD.

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Publishing Authors By Initials

M Ray,S Dharmarajan,J Freudenberg,W Zhang,GA Patterson,

For similar diagnosis: prognosis: treatment outcome: treatment failure research abstracts see: diagnosis: prognosis: treatment outcome: treatment failure research

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MEDLINE DATE:

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 2396-405

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 3

MONTH: Oct

YEAR: 2007

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100968638

Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Keywords Mesh Terms:

KEYWORDS: Treatment Failure

MESH TERMS: statistics & numerical data

Chemical & Substance for Abstract: Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Expression profiling of human donor lungs to understand primary graft dysfunction after lung transplantation.

AFFILIATION: Washington University School of Engineering, Department of Computer Science and Engineering, St. Louis, MO, USA.

Country: Denmark

AGENCY: United States NHLBI

GRANT: R01 HL41281

ACRONYM: HL

MEDLINETA: Am J Transplant

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