Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor.

Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Research Abstract Details 

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Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Abstract Text:

A Baranova,S Gowder,S Naouar,S King,K Schlauch,M Jarrar,Y Ding,B Cook,V Chandhoke,A Christensen,

Epithelial ovarian tumors are the most common subtype of ovarian cancer. In this study, we reveal distinct expression signatures of previously uncharacterized ovarian carcinoma subtypes, including endometrioid component of mixed ovarian tumor and Sertoli-Leydig tumor. Both subtypes were compared to the most common and well-characterized ovarian epithelial carcinoma of the serous type. These comparisons were performed by complementaryDNA (cDNA) microarrays allowing high-fidelity measurements of the expression levels of 39,360 human individual cDNA species representing both known and unknown human genes. Functional analysis of differentially expressed genes in Sertoli-Leydig tumor revealed an upregulation in sonic hedgehog pathway, deregulation of several metabolic pathways especially in amino acid metabolism and overexpression of genes associated with protein synthesis, including ribosomal genes.

Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Publishing Authors By Initials

A Baranova,S Gowder,S Naouar,S King,K Schlauch,M Jarrar,Y Ding,B Cook,V Chandhoke,A Christensen,

For similar neoplasms: neoplasms by histologic type: neoplasms, gonadal tissue: sex cord-gonadal stromal tumors: sertoli-leydig cell tumor research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, gonadal tissue: sex cord-gonadal stromal tumors: sertoli-leydig cell tumor research

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Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of gynecological cancer : of

VOLUME: 16

Page Numbers: 1963-72

Journal Abbreviation: Int. J. Gynecol. Cancer

ISSN: 1048-891X

DAY: 3

MONTH: 12

YEAR: 2007

Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Information

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LANGUAGE: eng

NlmUniqueID: 9111626

Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Keywords Mesh Terms:

KEYWORDS: Sertoli-Leydig Cell Tumor

MESH TERMS: pathology

Chemical & Substance for Abstract: Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Expression profile of ovarian tumors: distinct signature of Sertoli-Leydig cell tumor.

AFFILIATION: Molecular Biology and Microbiology, George Mason University, Fairfax, Virginia 22030, USA. abaranov@gmu.edu

Country: United States

AGENCY: United States NCI

GRANT: 1R15CA113331-01

ACRONYM: CA

MEDLINETA: Int J Gynecol Cancer

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