[Expression profile of immune associated genes in nasal polyps]

[Expression profile of immune associated genes in nasal polyps] Research Abstract Details 

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[Expression profile of immune associated genes in nasal polyps] Abstract Text:

Xin Wang,Zhen Dong,

OBJECTIVE: To investigate the expression profile of immune associated genes in nasal polyps by gene chip technology and to probe into the role of correlative genes in the immune pathogenesis of nasal polyps. METHODS: Microarray analysis was used to find the expressing profile of 491 immune associated genes in nasal polyps. The total RNAs were respectively extracted from four samples of nasal polyps and inferior turbinates, and then were reversely transcribed to cDNAs with incorporation of fluorescent dUTP as the hybridization probes. The mixed probes were then hybridized with two pieces of immune associated gene chip. It was scanned by laser scanner and the acquired image was analyzed by software. RESULTS: Eighty-seven genes were differently expressed in immune associated gene profile of nasal polyps, among which 45 genes were upregulated and 42 genes were down regulated. Fifteen genes were shown differential expression in both chips with 5 upregulated genes and 10 downregulated genes. The differentially expressed genes mostly involved in cytokines and their receptors, chemokines and their receptors, adhesion molecules, leukocytes differential antigens, immune signal transduction molecules, and still included some genes about complements and their receptors, immune transcription regulatory molecules, innate immune molecules and neural immune molecules. CONCLUSIONS: The differently expressed genes in immune associated gene chips will provide clues and theoretical foundation for the pathogenesis of nasal polyps. Furthermore IL-17 may have an important role in the occurrence of nasal polyps, and the role of innate immunity and immune signal transduction molecules in the pathogenesis of nasal polyps need further researches.

[Expression profile of immune associated genes in nasal polyps] Publishing Authors By Initials

X Wang,Z Dong,

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[Expression profile of immune associated genes in nasal polyps] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua er bi yan hou ke za zhi

VOLUME: 39

Page Numbers: 721-4

Journal Abbreviation: Zhonghua Er Bi Yan Hou Ke Za Z

ISSN: 0412-3948

DAY: 7

MONTH: Dec

YEAR: 2004

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LANGUAGE: chi

NlmUniqueID: 16210350

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Grant and Affiliation Information for [Expression profile of immune associated genes in nasal polyps]

AFFILIATION: Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Friendship Hospital, Ji Lin University, Changchun 130031, China.

Country: China

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MEDLINETA: Zhonghua Er Bi Yan Hou Ke Za Z

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