Expression profile of Bag 1 in the postmortem brain.

Expression profile of Bag 1 in the postmortem brain. Research Abstract Details 

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Expression profile of Bag 1 in the postmortem brain. Abstract Text:

Christine Curcio,John J Asheld,Janet M Chabla,Diana Ayubcha,Brian H Hallas,Judith M Horowitz,German Torres,

Bag 1 is a protein intimately involved in signaling pathways that regulate cell survival. Here we examined the expression profile of Bag 1 in the brain to consider issues associated with the sampling of anti-apoptotic proteins in a rat model of the human postmortem process. Following a 4h postmortem interval, we analyzed the hippocampus of rats maintained at 24 or 4 degrees C storage temperatures using immunocytochemical and Western blotting techniques. Remarkably, postmortem tissue (up to 4h) showed a significant and prominent up-regulation of Bag 1 in CA1 and CA3 subfields of the hippocampal formation. Over-expression of Bag 1, however, could only be traced down to a storage temperature of 24 degrees C. These data suggest that storage temperatures, but not postmortem intervals, significantly affect the expression profile and cellular stability of Bag 1 proteins.

Expression profile of Bag 1 in the postmortem brain. Publishing Authors By Initials

C Curcio,JJ Asheld,JM Chabla,D Ayubcha,BH Hallas,JM Horowitz,G Torres,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Expression profile of Bag 1 in the postmortem brain. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of chemical neuroanatomy

VOLUME: 32

Page Numbers: 191-5

Journal Abbreviation: J. Chem. Neuroanat.

ISSN: 0891-0618

DAY: 13

MONTH: 10

YEAR: 2006

Expression profile of Bag 1 in the postmortem brain. Information

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LANGUAGE: eng

NlmUniqueID: 8902615

Expression profile of Bag 1 in the postmortem brain. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiology

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Registry Number: 0

Grant and Affiliation Information for Expression profile of Bag 1 in the postmortem brain.

AFFILIATION: Department of Neuroscience, New York College of Osteopathic Medicine of New York Institute of Technology, Old Westbury, NY 11568, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: R15 MH064513-02A1

ACRONYM: MH

MEDLINETA: J Chem Neuroanat

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