Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma.

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Research Abstract Details 

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Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Abstract Text:

R O Pritchard-Jones,D B A Dunn,Y Qiu,A H R Varey,A Orlando,H Rigby,S J Harper,D O Bates,

Malignant melanoma is the most lethal of the skin cancers and the UK incidence is rising faster than that of any other cancer. Angiogenesis - the growth of new vessels from preexisting vasculature - is an absolute requirement for tumour survival and progression beyond a few hundred microns in diameter. We previously described a class of anti-angiogenic isoforms of VEGF, VEGF(xxx)b, that inhibit tumour growth in animal models, and are downregulated in some cancers, but have not been investigated in melanoma. To determine whether VEGF(xxx)b expression was altered in melanoma, PCR and immunohistochemistry of archived human tumour samples were used. In normal epidermis and in a proportion of melanoma samples, VEGF(xxx)b staining was seen. Some melanomas had much weaker staining. Subsequent examination revealed that expression was significantly reduced in primary melanoma samples (both horizontal and vertical growth phases) from patients who subsequently developed tumour metastasis compared with those who did not (analysis of variance (ANOVA) P<0.001 metastatic vs nonmetastatic), irrespective of tumour thickness, while the surrounding epidermis showed no difference in expression. Staining for total VEGF expression showed staining in metastatic and nonmetastatic melanomas, and normal epidermis. An absence of VEGF(xxx)b expression appears to predict metastatic spread in patients with primary melanoma. These results suggest that there is a switch in splicing as part of the metastatic process, from anti-angiogenic to pro-angiogenic VEGF isoforms. This may form part of a wider metastatic splicing phenotype.

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Publishing Authors By Initials

RO Pritchard-Jones,DB Dunn,Y Qiu,AH Varey,A Orlando,H Rigby,SJ Harper,DO Bates,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

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Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: British journal of cancer

VOLUME: 97

Page Numbers: 223-30

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 26

MONTH: 06

YEAR: 2007

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370635

Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma. Information

Substance Name: Vascular Endothelial Growth Factor A

Registry Number: 0

Grant and Affiliation Information for Expression of VEGF(xxx)b, the inhibitory isoforms of VEGF, in malignant melanoma.

AFFILIATION: Microvascular Research Laboratories, Department of Physiology, Preclinical Veterinary School, University of Bristol, Bristol, UK.

Country: England

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MEDLINETA: Br J Cancer

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