Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain.

Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Research Abstract Details 

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Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Abstract Text:

Jason R Gerstner,Charles F Landry,

The transcription coactivator CITED1 is an important mediator of transcriptional events regulated by estrogen or TGF-beta. We used in situ hybridization to delineate the distribution of CITED1 mRNA in the adult and developing murine brain and found robust CITED1 expression in ventral hypothalamus and midbrain raphe. The distribution of CITED1 in these regions overlapped the reported expression of estrogen receptors alpha and beta. Less intense expression of CITED1 was also evident in medial preoptic area, subfornical organ, thalamus and cerebral cortex. CITED1 mRNA in the arcuate nucleus (an area of active transcriptional modulation by TGF-beta) was evident in postmigratory neurons as early as embryonic day 16. Expression of CITED1 in arcuate continued throughout postnatal development. CITED1 in developing cerebellum was first evident in external granule cells and was transiently expressed in the Purkinje cell/granule cell layer in a temporal pattern similar to estrogen receptor-beta. The spatial and temporal distribution of CITED1 mRNA reported here is consistent with a role for CITED1 in the modulation of transcriptional events mediated by steroid hormone and cytokine signaling pathways.

Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Publishing Authors By Initials

JR Gerstner,CF Landry,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Developmental neuroscience

VOLUME: 29

Page Numbers: 203-12

Journal Abbreviation: Dev. Neurosci.

ISSN: 0378-5866

DAY: 17

MONTH: 10

YEAR: 2006

Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7809375

Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain. Information

Substance Name: Transforming Growth Factor beta

Registry Number: 0

Grant and Affiliation Information for Expression of the transcriptional coactivator CITED1 in the adult and developing murine brain.

AFFILIATION: Neuroscience Training Program, University of Wisconsin-Madison, 53711, USA.

Country: Switzerland

AGENCY: United States NIDA

GRANT: DA13780

ACRONYM: DA

MEDLINETA: Dev Neurosci

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