Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability.

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Research Abstract Details 

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Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Abstract Text:

K R Vella,A S Burnside,K M Brennan,D J Good,

Mice with a deletion of the hypothalamic basic helix-loop-helix transcription factor Nhlh2 display adult onset obesity, implicating Nhlh2 in the neuronal circuits regulating energy availability. Nhlh2 colocalises with the hypothalamic thyrotrophin-releasing hormone (TRH) neurones in the paraventricular nucleus (PVN) and pro-opiomelanocortin (POMC) neurones in the arcuate nucleus. We show that Nhlh2 expression is significantly reduced in response to 24-h food deprivation in the arcuate nucleus, PVN, lateral hypothalamus, ventromedial hypothalamus (VMH) and dorsomedial hypothalamus (DMH). Food intake for 2 h following deprivation stimulates Nhlh2 expression in the arcuate nucleus and the PVN, and leptin injection following deprivation results in increased Nhlh2 expression in the arcuate nucleus, PVN, lateral hypothalamus, VMH, and DMH. Hypothalamic Nhlh2 expression in response to leptin injection is maximal by 2 h. Following leptin injection, Nhlh2 mRNA colocalises in POMC neurones in the arcuate nucleus and TRH neurones in the PVN. Nhlh2 mRNA expression in POMC neurones in the arcuate nucleus and TRH neurones in the PVN is reduced with energy deprivation and is stimulated with food intake and leptin injection. Modulation of POMC expression in response to changes in energy availability is not affected in mice with a targeted deletion of Nhlh2. However, deletion of Nhlh2 does result in loss of normal TRH mRNA expression in mice exposed to food deprivation and leptin stimulation. These data implicate Nhlh2 as a regulatory target of the leptin-mediated energy availability network of the hypothalamus, and TRH as a putative downstream target of Nhlh2.

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Publishing Authors By Initials

KR Vella,AS Burnside,KM Brennan,DJ Good,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pituitary hormone-releasing hormones: thyrotropin-releasing hormone research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pituitary hormone-releasing hormones: thyrotropin-releasing hormone research

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Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroendocrinology

VOLUME: 19

Page Numbers: 499-510

Journal Abbreviation: J. Neuroendocrinol.

ISSN: 0953-8194

DAY: 3

MONTH: Jul

YEAR: 2007

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Information

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LANGUAGE: eng

NlmUniqueID: 8913461

Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Keywords Mesh Terms:

KEYWORDS: Thyrotropin-Releasing Hormone

MESH TERMS: genetics

Chemical & Substance for Abstract: Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability. Information

Substance Name: Pro-Opiomelanocortin

Registry Number: 66796-54-1

Grant and Affiliation Information for Expression of the hypothalamic transcription factor Nhlh2 is dependent on energy availability.

AFFILIATION: Department of Veterinary and Animal Sciences, Center for Neuroendocrine Studies, University of Massachusetts, Amherst, MA, USA.

Country: England

AGENCY: United States NIDDK

GRANT: DK-59903

ACRONYM: DK

MEDLINETA: J Neuroendocrinol

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