Expression of respiratory mucins in fatal status asthmaticus and mild asthma.

Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Research Abstract Details 

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Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Abstract Text:

D A Groneberg,P R Eynott,S Lim,T Oates,R Wu,I Carlstedt,P Roberts,B McCann,A G Nicholson,B D Harrison,K F Chung,

AIMS: The airways of patients with asthma are characterized by chronic inflammatory changes comprising mainly T-cells and eosinophils, and airway remodelling with goblet cell metaplasia and submucosal gland hyperplasia. Mucus hypersecretion is often a marked feature, particularly in status asthmaticus. The matrix of airway sputum consists of high molecular glycoproteins and mucins. In this study, the expression and distribution of the major gel-forming mucins MUC5AC and MUC5B were studied in fatal status asthmaticus tissues and bronchial biopsies of mild asthmatic patients. The effect of inhaled corticosteroids on the expression of these mucins was also investigated. METHODS AND RESULTS: Polyclonal antibodies specific for MUC5AC and MUC5B, and a monoclonal antibody for MUC5B were used to stain lung tissues and airway mucosal biopsies obtained from patients who died of status asthmaticus (n=5) and from mild asthmatics (n=4), respectively. Immunohistochemistry for MUC5AC revealed abundant staining of goblet cells situated in the epithelial surface lining and glandular ducts of tissues from patients with fatal asthma. MUC5B immunoreactivity was restricted to mucous cells of submucosal glands and to epithelial cells. In mild asthmatics, large amounts of MUC5B, but not MUC5AC, positive extracellular mucus was found in the airway lumen as plugs, adjacent to the epithelial lining and in the necks of glandular secretory ducts of mild asthmatics. The distribution of MUC5AC and MUC5B in bronchial biopsies of mild asthmatics was similar before and after inhaled steroid treatment. CONCLUSIONS: The expression of MUC5AC and MUC5B shares a similar distribution to normal airways in different states of asthma. The distribution is not affected by topical corticosteroid therapy.

Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Publishing Authors By Initials

DA Groneberg,PR Eynott,S Lim,T Oates,R Wu,I Carlstedt,P Roberts,B McCann,AG Nicholson,BD Harrison,KF Chung,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Histopathology

VOLUME: 40

Page Numbers: 367-73

Journal Abbreviation: Histopathology

ISSN: 0309-0167

DAY: 29

MONTH: Apr

YEAR: 2002

Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Information

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LANGUAGE: eng

NlmUniqueID: 7704136

Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: pathology

Chemical & Substance for Abstract: Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Expression of respiratory mucins in fatal status asthmaticus and mild asthma.

AFFILIATION: Thoracic Medicine, National Heart & Lung Institute, Imperial College of Science Technology & Medicine, London, UK.

Country: England

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MEDLINETA: Histopathology

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