Expression of polycomb group protein EZH2 in nevi and melanoma.

Expression of polycomb group protein EZH2 in nevi and melanoma. Research Abstract Details 

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Expression of polycomb group protein EZH2 in nevi and melanoma. Abstract Text:

Jonathan B McHugh,Douglas R Fullen,Linglei Ma,Celina G Kleer,Lyndon D Su,

BACKGROUND: Enhancer of zeste homolog 2 (EZH2), a polycomb group protein that regulates the cell cycle, has recently been implicated in the progression of several human cancers. We sought to determine the pattern of EZH2 expression in benign and malignant melanocytic tumors to see if EZH2 might play a role in melanoma pathogenesis and progression. METHODS: We identified and reviewed 11 compound nevi, 13 dysplastic nevi, 13 Spitz nevi, 9 in situ melanomas, 10 non-metastatic invasive melanomas and 19 melanomas metastatic to lymph nodes from the University of Michigan pathology archives. Sections immunostained with anti-EZH2 antibody were scored independently and blindly for staining intensity on a scale of 1-4 by three dermatopathologists. Results were analyzed and compared statistically. RESULTS: We observed an incremental increase in EZH2 expression from benign nevi to melanoma: scores of 1.18 and 1.08 for ordinary and dysplastic nevi, 1.7 and 1.78 for Spitz nevi and in situ melanoma, and 1.9 and 3.0 for invasive and metastatic melanoma, respectively. EZH2 expression for metastatic melanoma was significantly higher compared with invasive and in situ melanoma and benign nevi (p < or = 0.01). CONCLUSIONS: EZH2 protein levels increase incrementally from benign nevi to melanoma, which suggests that EZH2 may play a role in the pathogenesis and progression of melanoma.

Expression of polycomb group protein EZH2 in nevi and melanoma. Publishing Authors By Initials

JB McHugh,DR Fullen,L Ma,CG Kleer,LD Su,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Expression of polycomb group protein EZH2 in nevi and melanoma. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of cutaneous pathology

VOLUME: 34

Page Numbers: 597-600

Journal Abbreviation: J. Cutan. Pathol.

ISSN: 0303-6987

DAY: 3

MONTH: Aug

YEAR: 2007

Expression of polycomb group protein EZH2 in nevi and melanoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 425124

Expression of polycomb group protein EZH2 in nevi and melanoma. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of polycomb group protein EZH2 in nevi and melanoma. Information

Substance Name: polycomb group proteins

Registry Number: 0

Grant and Affiliation Information for Expression of polycomb group protein EZH2 in nevi and melanoma.

AFFILIATION: Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA.

Country: Denmark

AGENCY: United States NCI

GRANT: R01 CA 107469

ACRONYM: CA

MEDLINETA: J Cutan Pathol

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