Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors.

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Research Abstract Details 

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Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Abstract Text:

Sohei Yamamoto,Hitoshi Tsuda,Masashi Takano,Tsunekazu Kita,Kazuya Kudoh,Kenichi Furuya,Seiichi Tamai,Osamu Matsubara,

Recent studies have shown that platelet-derived growth factors and their receptors are frequently co-expressed in ovarian cancers. Herein, we investigated the role of the platelet-derived growth factor pathway in the development of ovarian clear-cell adenocarcinoma, a highly chemoresistant form of ovarian cancer. Immunohistochemical expression of platelet-derived growth factor receptor-alpha and receptor-beta, platelet-derived growth factor A-chain and B-chain was examined in 31 cases of clear-cell adenocarcinoma and 56 coexisting putative precursor lesions: 17 non-atypical and 19 atypical endometrioses, and 10 non-atypical and 10 atypical clear-cell adenofibroma components. Twenty-one solitary endometrioses were also examined. Vascular endothelial cells were always positive for all the markers examined, and were used as positive controls. The frequencies of positivity for platelet-derived growth factor receptor-alpha and receptor-beta, and platelet-derived growth factor A-chain increased in accordance with higher cytologic atypia in the putative precursors: 71, 47, and 59% in the 17 non-atypical endometrioses, 84, 73, and 84% in the 19 atypical endometrioses, 0% each in the 10 non-atypical clear-cell adenofibromas, 100, 90, and 90% in the 10 atypical clear-cell adenofibromas, and 97, 97, and 100% in the 31 clear-cell adenocarcinomas, respectively. Positivity for platelet-derived growth factor B-chain increased in accordance with increased atypia in clear-cell adenofibroma: 0% in non-atypical clear-cell adenofibromas, 30% in atypical clear-cell adenofibromas, and 60% in coexisting carcinomas. However, in contrast, positivity for platelet-derived growth factor B-chain decreased in accordance with increased atypia in endometriosis coexisting with clear-cell adenocarcinomas: 35% in non-atypical endometrioses, 11% in atypical endometrioses, and 5% in coexisting carcinomas. Platelet-derived growth factor receptor-alpha and receptor-beta, and their ligands A-chain and B-chain were positive in 14, 29, 19, and 62% of the solitary endometrioses, respectively. These results indicate activation of the platelet-derived growth factor pathway in ovarian clear-cell adenocarcinomas and suggest biological differences between carcinomas that arise in association with clear-cell adenofibroma vs endometriosis.Modern Pathology (2008) 21, 115-124; doi:10.1038/modpathol.3800984; published online 14 December 2007.

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Publishing Authors By Initials

S Yamamoto,H Tsuda,M Takano,T Kita,K Kudoh,K Furuya,S Tamai,O Matsubara,

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Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Modern pathology : an official journal of the Unit

VOLUME: 21

Page Numbers: 115-24

Journal Abbreviation: Mod. Pathol.

ISSN: 0893-3952

DAY: 14

MONTH: 12

YEAR: 2007

Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors.

AFFILIATION: 1Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama, Japan.

Country: United States

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