Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray.

Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Research Abstract Details 

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Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Abstract Text:

You Shi Liu,Chao Hui Yu,Lan Li,Bao Feng Zhang,Jing Fang,Qiong Zhou,Ying Hu,You Ming Li,Hen Jun Gao,

OBJECTIVE: The aim of this study was to obtain a comprehensive survey on the expression of p53, p16 and cyclooxygenase-2 (COX-2) in esophageal cancer progression and their clinical significance. METHODS: A tissue microarray containing 86 specimens from esophageal cancer and 40 specimens from adjacent non-cancer tissue was constructed to survey the expression of p53, p16 and COX-2 by immunohistochemistry. The influence of each biomarker on the histotype of esophageal lesion was assessed by logistic regression analysis. RESULTS: The expression of p53 and COX-2 was significantly higher in tumorous tissue than in non-tumorous tissue. As to p16, no significant difference was detected between tumorous and non-tumorous tissue. A significant correlation was observed among p53, COX-2 and p16 expression. Logistic regression analysis revealed that the risk factors of a tumorous histotype were the positive expression of p53 (odds ratio [OR] = 18.214) or COX-2 (OR = 42.703), and no reciprocal relationship to neoplastic progression was recognized with p53, p16 and COX-2. CONCLUSIONS: p53 and COX-2 were independent predictors in esophageal carcinogenesis. Esophageal tissue with a positive expression of p53 or COX-2 was more likely to develop esophageal cancer.

Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Publishing Authors By Initials

YS Liu,CH Yu,L Li,BF Zhang,J Fang,Q Zhou,Y Hu,YM Li,H Jun Gao,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of digestive diseases

VOLUME: 8

Page Numbers: 133-8

Journal Abbreviation:

ISSN: 1751-2972

DAY: 4

MONTH: Aug

YEAR: 2007

Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Information

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LANGUAGE: eng

NlmUniqueID: 101302699

Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray.

AFFILIATION: Department of Gastroenterology, First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, China.

Country: Australia

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MEDLINETA: J Dig Dis

REFSOURCE: J Dig Dis. 2007 Nov;8(4):222

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