[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines]

[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines] Research Abstract Details 

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[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines] Abstract Text:

Sulin Zhang,Weijia Kong,

OBJECTIVE: To study the expression of Neuropilin-1 in human carcinoma and papilloma of larynx specimens and carcinoma cell lines Hep-2. METHOD: The expression of Neuropilin-1 in human laryngeal carcinoma, papilloma specimens were investigated by immunohistochemical staining; the expression of Neuropilin-1 mRNA in human laryngeal squamous cell carcinoma, papilloma specimens and cell lines were examined by using RT-PCR. RESULT: Immunohistochemical analysis revealed that NRP-1 was expressed in all human laryngeal squamous cell carcinoma specimens but was absent in nonmalignant laryngeal tissue. The mRNA of NRP land Hep-2 cell lines are positive in 24 of 28 human laryngeal carcinoma specimens but not negative in nonmalignant laryngeal specimens. CONCLUSION: Neuropilin-1 was expressed in most of human laryngeal carcinoma specimens and cell lines but not expressed in nonmalignant tissue. It suggests that the expression of Neuropilin-1 may be related to the risk and development of laryngeal carcinoma and has high distinguishability.

[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines] Publishing Authors By Initials

S Zhang,W Kong,

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[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Lin chuang er bi yan hou ke za zhi = Journal of cl

VOLUME: 20

Page Numbers: 634-5

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ISSN: 1001-1781

DAY: 3

MONTH: Jul

YEAR: 2006

[Expression of neuropilin-1 in human laryngeal carcinoma and cell lines] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Expression of neuropilin-1 in human laryngeal carcinoma and cell lines]

AFFILIATION: Department of Otolaryngology Study, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.

Country: China

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MEDLINETA: Lin Chuang Er Bi Yan Hou Ke Za

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