Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis.

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Research Abstract Details 

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Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Abstract Text:

E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,

N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyses beta1-6 branching of N-acetylglucosamine on asparagine-linked oligosaccharides of cell proteins. The present study aimed to investigate GnT-V expression and its prognostic significance in endometrial cancer. N-acetylglucosaminyltransferase V expression was studied by immunohistochemistry in 74 surgically resected endometrial cancers, and the staining intensity was evaluated. High GnT-V expression in tumour cells was found in 43 (58.1%) of the 74 cases, and was positively correlated with advanced patient age, histological grade, and lymph vascular space involvement. Patients with high GnT-V expression had significantly impaired overall survival and progression-free survival (PFS) (P=0.0041 and P=0.0023, respectively) compared to patients with low expression of GnT-V. On multivariate analysis, GnT-V expression was an independent prognostic factor for PFS (P=0.0364). beta1-6 branching of asparagine-linked oligosaccharides was also detected in GnT-V-positive endometrial cancer cells by leukoagglutinating phytohaemagglutinin (L(4)-PHA) staining, and the molecular size of the major glycoproteins recognised by L(4)-PHA was approximately 60-200 kDa by lectin blot analysis. These results suggested that high GnT-V expression was correlated with an unfavourable clinical outcome, and that GnT-V is involved in the malignant potential of endometrial cancer by increasing the synthesis of beta1-6 branching of asparagine-linked oligosaccharides.British Journal of Cancer (2007) 97, 1538-1544. doi:10.1038/sj.bjc.6604044 www.bjcancer.com Published online 30 October 2007.

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Publishing Authors By Initials

E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,E Yamamoto,K Ino,E Miyoshi,K Shibata,N Takahashi,H Kajiyama,A Nawa,S Nomura,T Nagasaka,F Kikkawa,

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Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of cancer

VOLUME: 97

Page Numbers: 1538-44

Journal Abbreviation: Br. J. Cancer

ISSN: 0007-0920

DAY: 30

MONTH: 10

YEAR: 2007

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

Country: England

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MEDLINETA: Br J Cancer

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