Expression of mucins in mucoid otitis media.

Expression of mucins in mucoid otitis media. Research Abstract Details 

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Expression of mucins in mucoid otitis media. Abstract Text:

Jizhen Lin,Yasuhiro Tsuboi,Frank Rimell,George Liu,Katsuhiro Toyama,Hirokazu Kawano,Michael M Paparella,Samuel B Ho,

A hallmark of mucoid otitis media (MOM, i.e., chronic otitis media with mucoid effusion) is mucus accumulation in the middle ear cavity, a condition that impairs transduction of sounds in the ear and causes hearing loss. The mucin identities of mucus and the underlying mechanism for the production of mucins in MOM are poorly understood. In this study, we demonstrated that the MUC5B and MUC4 were major mucins in MOM that formed distinct treelike polymers (mucus strands). The MUC5B and MUC4 mRNAs in the middle ear mucosa with MOM were up regulated 5-fold and 6-fold, compared with the controls. This upregulation was accompanied by the extensive proliferation of the MUC5B- and MUC4-producing cells in the middle ear epithelium. Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells.

Expression of mucins in mucoid otitis media. Publishing Authors By Initials

J Lin,Y Tsuboi,F Rimell,G Liu,K Toyama,H Kawano,MM Paparella,SB Ho,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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Expression of mucins in mucoid otitis media. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the Association for Research in Otolary

VOLUME: 4

Page Numbers: 384-93

Journal Abbreviation: J. Assoc. Res. Otolaryngol.

ISSN: 1525-3961

DAY: 1

MONTH: Sep

YEAR: 2003

Expression of mucins in mucoid otitis media. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100892857

Expression of mucins in mucoid otitis media. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: analysis

Chemical & Substance for Abstract: Expression of mucins in mucoid otitis media. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Expression of mucins in mucoid otitis media.

AFFILIATION: Department of Otolaryngology, Otitis Media Research Center, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA. linxx004@tc.umn.edu

Country: United States

AGENCY: United States NIDCD

GRANT: R01 DC03433

ACRONYM: DC

MEDLINETA: J Assoc Res Otolaryngol

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