Expression of mucin genes in chronic ethmoiditis.

Expression of mucin genes in chronic ethmoiditis. Research Abstract Details 

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Expression of mucin genes in chronic ethmoiditis. Abstract Text:

H H Jung,J H Lee,Y T Kim,S D Lee,J H Park,

We have investigated the profiles of MUC genes expressed in chronic ethmoiditis mucosa and normal ethmoid mucosa using RT-PCR, and the morphology of chronic ethmoiditis by a combination of light and electron microscope was observed. In the light- and electron-microscopic studies, chronic ethmoiditis mucosa revealed increased numbers of goblet cells with higher production of mucus in comparison to normal ethmoid mucosa. RT-PCR of cDNAs from three normal ethmoid mucosa revealed the same pattern of mucin gene expression, such as MUC5AC and MUC8. However, RT-PCR of cDNAs from eight chronic ethmoiditis mucosa showed the expression of two MUC1, six MUC4, eight MUC5AC, five MUC5B, seven MUC7, and eight MUC8. MUC2 and MUC6 were not detected. These results suggest that MUC4, MUC5AC, MUC5B, MUC7, and MUC8 are major mucins in the ethmoid mucosa and are up-regulated by chronic inflammation.

Expression of mucin genes in chronic ethmoiditis. Publishing Authors By Initials

HH Jung,JH Lee,YT Kim,SD Lee,JH Park,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE: 2000 May-Jun

Expression of mucin genes in chronic ethmoiditis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of rhinology

VOLUME: 14

Page Numbers: 163-70

Journal Abbreviation:

ISSN: 1050-6586

DAY: 1

MONTH: 12

YEAR: 2007

Expression of mucin genes in chronic ethmoiditis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8807268

Expression of mucin genes in chronic ethmoiditis. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of mucin genes in chronic ethmoiditis. Information

Substance Name: mucin 6

Registry Number: 0

Grant and Affiliation Information for Expression of mucin genes in chronic ethmoiditis.

AFFILIATION: Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Republic of Korea.

Country: UNITED STATES

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MEDLINETA: Am J Rhinol

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