Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus.

Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. Research Abstract Details 

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Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. Abstract Text:

Lopes, Pereira-Lima, Hartmann,

BACKGROUND/AIMS: Hematoxylin-eosin stain may fail to show intestinal metaplasia in Barrett's esophagus, and PAS-alcian blue may present difficulties of interpretation due to its more heterogeneous staining. We investigated whether Mucin-2 is a good substitute for PAS-alcian blue in the detection of goblet cells. METHODOLOGY: Biopsy specimens from 47 Barrett's esophagus patients were stained with hematoxylineosin and PAS-alcian blue. Mucin-2 expression was evaluated with monoclonal antibody. The intra- and interobserver agreements about the expression of Mucin-2 and PAS-alcian blue stain were determined by kappa statistics. RESULTS: PAS-alcian blue and Mucin-2 were positive in all cases. Mucin expression was positive in goblet cells and few columnar cells. PAS-alcian blue showed heterogeneous staining. The columnar epithelium and the submucosal glands were also stained. Intra- and interobserver agreement in the identification of intestinal metaplasia was 100%. CONCLUSIONS: Mucin-2 agreed fully with PAS-alcian blue. The intra- and interobserver agreement was perfect, justifying its use in the diagnosis of Barrett's esophagus.

Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. Publishing Authors By Initials

CV Lopes,J Pereira-Lima,A Hartmann,

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Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hepato-gastroenterology

VOLUME: 53

Page Numbers: 511-5

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ISSN: 0172-6390

DAY: 30

MONTH: 11

YEAR: 2007

Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. Information

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LANGUAGE: eng

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AFFILIATION: Departmens of Gastroenterology, Porto Alegre School of Medical Sciences (FFFCMPA)/Santa Casa Hospital, Porto Alegre, Brazil. cevele@terra.com.br

Country: Greece

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MEDLINETA: Hepatogastroenterology

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