Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Research Abstract Details 

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Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Abstract Text:

D A Groneberg,P R Eynott,T Oates,S Lim,R Wu,I Carlstedt,A G Nicholson,K F Chung,

Hypersecretion of airway mucus is a characteristic feature of chronic airway diseases like cystic fibrosis (CF) and leads via impairment of the muco-ciliary clearance and bacterial superinfection to respiratory failure. The major components of the mucus matrix forming family of mucins in the airways are MUC5AC and MUC5B. To investigate the expression of these glycoproteins in CF, immunohistochemistry was carried out on trachea, bronchi and peripheral lung obtained from CF patients and compared to normal lung tissues. MUC5AC immunohistochemistry demonstrated signals in goblet cells of the epithelial lining. Also, goblet cells inside glandular secretory ducts revealed MUC5AC-positive staining. In comparison to those from normal subjects, CF sections were characterized by inflammatory changes and goblet cell hyperplasia, resulting in increased numbers of MUC5AC-positive cells. Immunohistochemical staining for MUC5B showed abundant staining of submucosal glands and epithelial goblet cells. Inside the glands, the immunoreactivity was restricted to glandular mucous cells. MUC5AC and MUC5B are expressed in the same histological pattern in CF compared to normal tissues with an increase of MUC5AC-positive cells due to goblet cell hyper- and metaplasia.

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Publishing Authors By Initials

DA Groneberg,PR Eynott,T Oates,S Lim,R Wu,I Carlstedt,AG Nicholson,KF Chung,

For similar respiratory system: trachea research abstracts see: respiratory system: trachea research

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Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Respiratory medicine

VOLUME: 96

Page Numbers: 81-6

Journal Abbreviation:

ISSN: 0954-6111

DAY: 29

MONTH: Feb

YEAR: 2002

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Information

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LANGUAGE: eng

NlmUniqueID: 8908438

Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Keywords Mesh Terms:

KEYWORDS: Trachea

MESH TERMS: chemistry

Chemical & Substance for Abstract: Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.

AFFILIATION: Thoracic Medicine, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK.

Country: England

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MEDLINETA: Respir Med

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