Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Research Abstract Details 

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Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Abstract Text:

Lars Wittler,Eun-ha Shin,Phillip Grote,Andreas Kispert,Anja Beckers,Achim Gossler,Martin Werber,Bernhard G Herrmann,

The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta-Notch signalling pathways control presomitic mesoderm (psm) formation and segmentation. Here, we show that the expression of mesogenin 1, a basic helix-loop-helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation.

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Publishing Authors By Initials

L Wittler,EH Shin,P Grote,A Kispert,A Beckers,A Gossler,M Werber,BG Herrmann,

For similar enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research abstracts see: enzymes and coenzymes: enzymes: hydrolases: glycoside hydrolases: galactosidases: beta-galactosidase research

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Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: EMBO reports

VOLUME: 8

Page Numbers: 784-9

Journal Abbreviation: EMBO Rep.

ISSN: 1469-221X

DAY: 13

MONTH: 07

YEAR: 2007

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100963049

Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Keywords Mesh Terms:

KEYWORDS: beta-Galactosidase

MESH TERMS: genetics

Chemical & Substance for Abstract: Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. Information

Substance Name: beta-Galactosidase

Registry Number: EC 3.2.1.23

Grant and Affiliation Information for Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.

AFFILIATION: Department of Developmental Genetics, Max-Planck-Institute for Molecular Genetics, Berlin, Germany.

Country: England

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MEDLINETA: EMBO Rep

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