Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis.

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis. Research Abstract Details 

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Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis. Abstract Text:

Koji Tsugawa,Eishin Oki,Koichi Suzuki,Tadaatsu Imaizumi,Etsuro Ito,Hiroshi Tanaka,

Recent studies have suggested that gene expression studies using urinary sediment might be a non-invasive approach to assessing activity and pathogenesis in glomerulonephritis. However, little information is available regarding the mRNA expression patterns of functional molecules, such as T-bet, GATA-3, FOXP3, and retinoic acid-inducible gene-I (RIG-I), in urinary sediment, from patients with immunocomplex-mediated glomerulonephritis. Fourteen lupus nephritis (LN) patients, 13 IgA nephropathy (IgAN) patients, and 12 healthy controls were enrolled in the study. The mRNA expressions of T-bet, GATA-3, FOXP3 and RIG-I in urinary sediment were measured using real time quantitative polymerase chain reaction. We also studied the expression of RIG-I in kidney tissue specimens obtained from LN and IgAN patients. Significant differences in the expression patterns of GATA-3, FOXP3 and RIG-I, and marginal differences in T-bet expression, were observed between the three study groups. Immunofluorescent staining for RIG-I was observed in the tissue specimens from the LN patients, but not in those from the IgAN patients. The mRNA expression patterns of T-bet, GATA-3, FOXP3 and RIG-I in urinary sediment differ according to diagnostic category. These results suggest that the measurement of these target gene expressions might be a useful, non-invasive method for clinical monitoring and studying of pathogenesis in glomerulonephritis.

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis. Publishing Authors By Initials

K Tsugawa,E Oki,K Suzuki,T Imaizumi,E Ito,H Tanaka,

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Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric nephrology (Berlin, Germany)

VOLUME: 23

Page Numbers: 395-401

Journal Abbreviation: Pediatr. Nephrol.

ISSN: 0931-041X

DAY: 19

MONTH: 12

YEAR: 2007

Expression of mRNA for functional molecules in urinary sediment in glomerulonephritis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pediatrics, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan, kojituga@royal.ocn.ne.jp.

Country: Germany

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MEDLINETA: Pediatr Nephrol

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