[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease]

[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease] Research Abstract Details 

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[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease] Abstract Text:

Chun-chu Kong,Ai-guo Dai,

OBJECTIVE: To investigate the expression of mitogen-actived protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K) and hypoxia-inducible factor-1alpha (HIF-1alpha) in pulmonary artery of chronic obstructive pulmonary disease (COPD), and therefore to explore the possible roles of MAPK, PI3K and HIF-1alpha in the development of hypoxia-induced pulmonary hypertension (HPH). METHODS: Small pulmonary arterial remodeling was observed by morphometric analysis in surgically removed lung tissues from COPD patients and control patients treated for lung tumors. The expression of p-ERK, p-JNK, p-P38, p-PKB and HIF-1alpha in lung tissue was examined by in situ hybridization and immunohistochemistry. RESULTS: Morphometry analysis showed that the ratio of wall area to total area (WA%) and pulmonary artery media thickness (PAMT) were increased in COPD patients [18 +/- 3, (31 +/- 3) microm] than in the control [30 +/- 5, (40 +/- 4) microm, t = 7.58, 6.57, all P < 0.01]. The expression levels of p-ERK protein, p-PKB protein, HIF-1alpha protein and HIF-1alpha mRNA level (absorbance, A) were significantly higher in pulmonary artery walls of COPD patients (0.164 +/- 0.012, 0.113 +/- 0.009, 0.232 +/- 0.008, 0.154 +/- 0.013, respectively) as compared to those of the control (0.062 +/- 0.010, 0.031 +/- 0.011, 0.058 +/- 0.006, 0.052 +/- 0.008, respectively, t = 23.18, 21.03, 62.14, 2.44, all P < 0.01), while p-JNK and p-P38 protein levels in the control group (0.048 +/- 0.013, 0.028 +/- 0.007, respectively) and COPD patients (0.041 +/- 0.012, 0.031 +/- 0.010, respectively, all P > 0.05) were barely positive. The expression of p-ERK, p-PKB and HIF-1alpha were negatively correlated with LA% (r = -0.920 - -0.892, all P < 0.05), and positively correlated with PAMT (r = 0.895 - 0.934, all P < 0.05). CONCLUSION: Differential expression of p-ERK, p-PKB and HIF-1alpha may be involved in the occurrence of HPH in COPD patients.

[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease] Publishing Authors By Initials

CC Kong,AG Dai,

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[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe h

VOLUME: 29

Page Numbers: 372-5

Journal Abbreviation: Zhonghua Jie He He Hu Xi Za Zh

ISSN: 1001-0939

DAY: 18

MONTH: Jun

YEAR: 2006

[Expression of mitogen-actived protein kinase, phosphatidylinositol 3-kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic obstructive pulmonary disease] Information

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LANGUAGE: chi

NlmUniqueID: 8712226

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AFFILIATION: Department of Respiratory Disease Research, Hunan Institute of Gerontology, Hunan Geriatric Hospital, Changsha 410001, China.

Country: China

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MEDLINETA: Zhonghua Jie He He Hu Xi Za Zh

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