Expression of MDR1 in epithelial ovarian cancer and its association with disease progression.

Expression of MDR1 in epithelial ovarian cancer and its association with disease progression. Research Abstract Details 

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Expression of MDR1 in epithelial ovarian cancer and its association with disease progression. Abstract Text:

Lingeng Lu,Dionyssios Katsaros,Andrew Wiley,Irene A Rigault de la Longrais,Manuela Puopolo,Herbert Yu,Lingeng Lu,Dionyssios Katsaros,Andrew Wiley,Irene A Rigault de la Longrais,Manuela Puopolo,Herbert Yu,

The purposes of this study were to analyze MDR1 expression in ovarian tumors prior to chemotherapy, to correlate the expression with p16, IGFs, ERalpha, and BRCA1, and to examine the association of MDR1 expression with ovarian cancer prognosis. A primary ovarian cancer cohort of 206 patients after surgery was followed up. MDR1, IGFs, ERalpha, p16, and BRCA1 expressions were analyzed in ovarian tumor samples using quantitative real-time PCR. MDR1 was detected in 177 of 206 specimens. MDR1 expression was positively correlated with IGFBP3, ERalpha, p16, and BRCA1, but not correlated with IGF-II, age, and other clinicopathological parameters. MDR1 expression significantly elevated the risk for disease progression (p = 0.02), and this association remained statistically significant after controlling for patient age and clinicopathological parameters or other correlated genes. No association was found between MDR1 expression and overall survival. MDR1 expression may be an independent marker for ovarian cancer progression and combination of different agents targeting different molecules may improve the outcome of ovarian cancer treatment and prevent drug resistance.

Expression of MDR1 in epithelial ovarian cancer and its association with disease progression. Publishing Authors By Initials

L Lu,D Katsaros,A Wiley,IA Rigault de la Longrais,M Puopolo,H Yu,L Lu,D Katsaros,A Wiley,IA Rigault de la Longrais,M Puopolo,H Yu,

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Expression of MDR1 in epithelial ovarian cancer and its association with disease progression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncology research

VOLUME: 16

Page Numbers: 395-403

Journal Abbreviation: Oncol. Res.

ISSN: 0965-0407

DAY: 4

MONTH: 10

YEAR: 2007

Expression of MDR1 in epithelial ovarian cancer and its association with disease progression. Information

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LANGUAGE: eng

NlmUniqueID: 9208097

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Grant and Affiliation Information for Expression of MDR1 in epithelial ovarian cancer and its association with disease progression.

AFFILIATION: Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520-8034, USA.

Country: United States

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MEDLINETA: Oncol Res

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