Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury.

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Abstract Text:

Kathleen E Rodgers,Dolph D Ellefson,Theresa Espinoza,Ya-hsuan Hsu,Gere S diZerega,Ruty Mehrian-Shai,

Reports have shown differences in gene expression in the skin of diabetic and normal mice both at baseline and after injury. Cluster analysis identified distinct expression patterns within intermediate filaments and extracellular proteins. This report addresses the effect of diabetes and injury on the expression of keratin-associated proteins, keratin complexes, procollagen, and collagenase (matrix metalloproteinase; MMP) genes. At baseline keratin-associated proteins and keratin complexes gene expression was increased in diabetic mice. After surgery, the level of expression for keratin-associated proteins and keratin complexes genes decreased in diabetic mice, but did not change in normal mice. If the expression of a procollagen gene differed between diabetic and normal mice, the expression was lower in diabetic mice. Procollagen gene expression was elevated after skin excision compared with noninjured skin. At baseline, the level of MMP and tissue inhibitor of metalloproteinase gene expression was comparable between mouse strains. With injury, the expression of several MMP genes was increased in both mouse strains, but to higher levels in diabetic mice. At day 7, the level of MMP-9 activity in granulation tissue was elevated. This alteration may contribute to delayed healing in diabetic mice. Therefore, differences in gene expression exist between mouse strains and can assist in understanding of physiological manifestations, including delayed healing, in diabetic mice.

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Publishing Authors By Initials

KE Rodgers,DD Ellefson,T Espinoza,YH Hsu,GS diZerega,R Mehrian-Shai,

For similar proteins: tissue inhibitor of metalloproteinases research abstracts see: proteins: tissue inhibitor of metalloproteinases research

PUBMED ID PMID:

MEDLINE DATE:

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Wound repair and regeneration : official publicati

VOLUME: 14

Page Numbers: 298-305

Journal Abbreviation:

ISSN: 1067-1927

DAY: 3

MONTH: 12

YEAR: 2007

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9310939

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Keywords Mesh Terms:

KEYWORDS: Tissue Inhibitor of Metalloproteinases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury. Information

Substance Name: Matrix Metalloproteinases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury.

AFFILIATION: Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California 90033, USA. krodgers@usc.edu

Country: United States

AGENCY: United States NIAMS

GRANT: 5R44AR047481-03

ACRONYM: AR

MEDLINETA: Wound Repair Regen

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury Related Publications

• Expression of intracellular filament, collagen, and collagenase genes in diabetic and normal skin after injury.
• Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication.