Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver.

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Abstract Text:

Fu Yang,Shikai Yan,Ying He,Fang Wang,Shuxia Song,Yingjun Guo,Qi Zhou,Yue Wang,Zhongying Lin,Yun Yang,Weidong Zhang,Shuhan Sun,Fu Yang,Shikai Yan,Ying He,Fang Wang,Shuxia Song,Yingjun Guo,Qi Zhou,Yue Wang,Zhongying Lin,Yun Yang,Weidong Zhang,Shuhan Sun,

BACKGROUND/AIMS: Hepatitis B virus transgenic mice (HBV-Tg mice) have been widely used as animal models in the study of pathogenesis and control of hepatitis B. It is important for the evaluation of such animal models to define the physiological differences between HBV-Tg and wild-type mice. The aim of this research was to investigate whether the integrated system biology approach that combines proteomics and metabonomics describes the physiological changes and provides new insights into the pathogenesis of the early stages of HBV infection. METHODS: In this study the protein and metabolite profiles of the liver were established based on two-dimensional electrophoresis and HPLC/MS analysis. RESULTS: Several protein molecules, whose expression was altered in HBV-Tg mouse liver, were identified including protective enzymes against oxidative stress and regulatory proteins related to lipid metabolism. Metabonomics confirmed the potential derangement of lipid metabolism by discovering the intermediate and the final products of lipid metabolism that were markedly changed in transgenic mice. CONCLUSIONS: This study demonstrated that HBV antigens could impair host cell lipid metabolism and induce modest oxidative stress in vivo.

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Publishing Authors By Initials

F Yang,S Yan,Y He,F Wang,S Song,Y Guo,Q Zhou,Y Wang,Z Lin,Y Yang,W Zhang,S Sun,F Yang,S Yan,Y He,F Wang,S Song,Y Guo,Q Zhou,Y Wang,Z Lin,Y Yang,W Zhang,S Sun,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of hepatology

VOLUME: 48

Page Numbers: 12-9

Journal Abbreviation: J. Hepatol.

ISSN: 0168-8278

DAY: 10

MONTH: 09

YEAR: 2007

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8503886

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver.

AFFILIATION: Department of Medical Genetics, Second Military Medical University, 800 Xiang-Yin Road, Shanghai 200433, PR China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Hepatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver Related Publications

• Circadian clock genes oscillate in human peripheral blood mononuclear cells.
• Lumbar spinal fusion with a mineralized collagen matrix and rhBMP-2 in a rabbit model.
• Regulatory peptides modulate ICAM-1 gene expression and NF-kappaB activity in bronchial epithelial cells.
• [A comparative study of EGFR and FGFR-2 expression in fetal and adult skin]
• [A monitoring study of electromyography median frequency on fatigue of erector spinalis in drivers working at high altitude]
• [Achievements in the research on filariasis in China in the past 50 years]
• [An experiment to study the treatment of sarcomas by electroporation]
• [An observation of the effects of Tiopronin on the oxygen free radicals in severely scalded rats receiving delayed fluid resuscitation]
• [Analysis on genetic polymorphism of 14 short tandem repeat loci on chromosome 7p14-15 and 12q13 in Chinese north Hans]
• [Application of noninvasive hemodynamic monitoring in patients with heart failure caused by chronic pulmonary heart diseases]
• [Colocalization of 11beta-hydroxysteroid dehydrogenase type I and glucocorticoid receptor and its significance in rat hippocampus]
• [Effect of "yang wei kang liu" granula on expression of P53 and PCNA in mice bearing sarcoma 180]
• [Effects of ATP concentration and hypoxic exposure on RNA and protein synthesis activity in isolated mitochondria from rat brain]
• [Effects of Ulinastatin on the intestinal mucosal barrier of the mini-pigs after severe burn injury]
• [Expression of recombinant human Flt3 ligand in Escherichia coli and its purification and characterization]
• [Expression of transporter associated with antigen processing (TAP) in childhood acute leukemia and its clinical significance]
• [Influence of prostaglandin E2 on proliferation of melanocytes in full-thickness skin graft]
• [Investigation and evaluation on the harmfulness of partial vibration and the contact vibration time]
• [Okadaic acid induces the expression of glutamate transporter EAAT1 in the neurons of rat brain]
• [Pathology and pathophysiology of severe acute respiratory syndrome]
• [Protective effect of exogenous bcl-2 on spinal cord motoneurons following sciatic nerve axotomy in the rat]
• [Risk factors for malignant pleural mesothelioma in crocidolite contaminated area]
• [Selection of vestibular system function in Chinese astronauts]
• [Spatial autocorrelation analysis on schistosomiasis cases and Oncomelania snails in three provinces of the lower reach of Yangtze River]
• [Studies on crosslinkable coatings for biomedical application]
• [Study on the relationship between the opacity of lens and the levels of 2, 6-dinitro-4-amino-toluene (DNAT) in the urine of workers exposed to trinitrotoluene(TNT)]
• [The association between glucocorticoid receptor gene G1666T polymorphism and cerebral infarction in Chinese]
• [The effects of NO inhalation on cardice function in the burn patients with inhalation injury]
• [The expression of nestin in ischemia-injured brain of adult rat]
• [The neuromuscular transmission effects induced by pralidoxine chloride on rats with acute isocarbophos poisoning]