Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea.

Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Research Abstract Details 

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Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Abstract Text:

A Kinder,A Sierts-Herrmann,S Biselli,N Heinzel,H ,U Kammann,N Reineke,N Theobald,H Steinhart,

Heat shock proteins 70 (hsp70) are known to be induced by a great variety of chemical stressors. The effects of different environmental contaminants, which were identified in sediments of the North Sea and the Baltic Sea as main contaminants or as contaminants of special toxicological interest, on the extent of expression of hsp70 in a permanent cell line Epithelioma papulosum cyprini (EPC) were investigated. Concentrations of the single contaminants leading to elevated hsp70 levels were compared to the respective concentrations of these contaminants encountered in the sediment extracts thus allowing an assessment of their contribution to the toxicity of these sediments. Analysis of hsp70 was performed using western blotting techniques with subsequent comparative quantification by densitometry. Eleven of thirteen contaminants have shown a dose-dependent increase in hsp70 levels. An expression of hsp70 was observed in most cases between 0.1 and 10 microg/mL test solution. Some of the investigated stressors led to extremely high hsp70 contents even at low concentrations. However, in most cases contaminant concentrations in sediments were too low to cause an effect. For this reason, effects of the tested sediments are attributed to other contaminants or rather to mixtures of stressors.

Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Publishing Authors By Initials

A Kinder,A Sierts-Herrmann,S Biselli,N Heinzel,H ,U Kammann,N Reineke,N Theobald,H Steinhart,

For similar geographic locations: oceans and seas: atlantic ocean: north sea research abstracts see: geographic locations: oceans and seas: atlantic ocean: north sea research

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Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Marine environmental research

VOLUME: 63

Page Numbers: 506-15

Journal Abbreviation: Mar. Environ. Res.

ISSN: 0141-1136

DAY: 7

MONTH: 02

YEAR: 2007

Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Information

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LANGUAGE: eng

NlmUniqueID: 9882895

Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Keywords Mesh Terms:

KEYWORDS: North Sea

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea. Information

Substance Name: L-Lactate Dehydrogenase

Registry Number: EC 1.1.1.27

Grant and Affiliation Information for Expression of heat shock protein 70 in a permanent cell line (EPC) exposed to sediment extracts from the North Sea and the Baltic Sea.

AFFILIATION: University of Hamburg, Institute of Biochemistry and Food Chemistry, Grindelallee 117, 20146 Hamburg, Germany.

Country: England

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MEDLINETA: Mar Environ Res

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