Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats.

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Abstract Text:

Takahiro Sonomura,Kouichi Nakamura,Takahiro Furuta,Hiroyuki Hioki,Akinori Nishi,Atsushi Yamanaka,Masanori Uemura,Takeshi Kaneko,Takahiro Sonomura,Kouichi Nakamura,Takahiro Furuta,Hiroyuki Hioki,Akinori Nishi,Atsushi Yamanaka,Masanori Uemura,Takeshi Kaneko,

Neostriatal projection neurons are known to be largely divided into two groups, striatoentopeduncular/striatonigral and striatopallidal neurons, which mainly express D1 and D2 dopamine receptors, respectively. Recently, a small population of neostriatal neurons have been reported to produce neurokinin B (NKB), and send their axons mainly to the basal forebrain regions. To reveal which type of dopamine receptors were expressed by these NKB-producing neurons, we examined rat striatal neurons by combining immunofluorescence labeling for preprotachykinin B (PPTB), the precursor of NKB, and fluorescence in situ hybridization labeling for dopamine receptors. Fluorescent signals for D1 receptor mRNA were detected in 85-89% of PPTB-immunopositive neurons in the neostriatum, accumbens nucleus and lateral stripe of the striatum, whereas almost no signal for D2 receptor was observed in PPTB-positive striatal neurons. To further reveal intracellular signaling downstream of D1 receptor in PPTB-producing neurons, we used a double immunofluorescence labeling method to study the localization of some substrates for protein kinase A (PKA), which was known to be activated by D1 receptor. Although only 3-7% of PPTB-immunopositive striatal neurons displayed immunoreactivity for dopamine- and cAMP-regulated phosphoprotein of 32 kDa, a well-known PKA substrate expressed in the two major groups of neostriatal projection neurons, 60-64% of PPTB-positive striatal neurons exhibited immunoreactivity for striatal-enriched tyrosine phosphatase. These results suggest that NKB-producing neostriatal neurons are similar to striatoentopeduncular/striatonigral neurons in the usage of dopamine receptor subtypes, but different from the two major groups of neostriatal projection neurons in terms of the downstream signaling of dopamine receptors.

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Publishing Authors By Initials

T Sonomura,K Nakamura,T Furuta,H Hioki,A Nishi,A Yamanaka,M Uemura,T Kaneko,T Sonomura,K Nakamura,T Furuta,H Hioki,A Nishi,A Yamanaka,M Uemura,T Kaneko,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The European journal of neuroscience

VOLUME: 26

Page Numbers: 3093-103

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 21

MONTH: Dec

YEAR: 2007

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats.

AFFILIATION: Department of Anatomy for Oral Sciences, Graduate School of Medical and Dental Sciences, Advanced Therapeutic Course, Field of Neurology, Kagoshima University, Kagoshima 890-8544, Japan.

Country: France

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats Related Publications

• A structural and phylogenetic study of the HO gene from Saccharomyces bayanus var. uvarum.
• Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethanphetamine (MDMA) under acidic conditions.
• Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A*24 tetramers during phlebotomy and interferon therapy for chronic hepatitis C.
• Association between condom use and perceived barriers to and self-efficacy of safe sex among young women in Japan.
• Cerebral edema in a child with diabetic ketoacidosis before initial treatment.
• Direction dependent response of human skin.
• Discreteness-induced transition in catalytic reaction networks.
• Double-step gas sorption of a two-dimensional metal-organic framework.
• Effective electroconvulsive therapy in a 92-year-old dementia patient with psychotic feature.
• Epinephrine in local anesthetic cancels increase in tongue mucosal blood flow after stellate ganglion block in rabbit.
• Erythrocyte invasion: vocabulary and grammar of the Plasmodium rhoptry.
• Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus.
• Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat.
• Lichenoid drug eruption of nails induced by propylthiouracil.
• Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.
• Perceived depth in the 'sieve effect' and exclusive binocular rivalry.
• Question 8: from a set of chemical reactions to reproducing cells.
• Question 9: minority control and genetic takeover.
• Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.
• Skin surface shock wave.
• Surgical strategy for advanced gastric cancer with a concomitant thoracoabdominal aortic aneurysm requiring arterial reconstruction of the visceral branches.
• Systemic sclerosis complicated by ovarian cancer.
• Temporospatial patterns of COX-2 expression and pyramidal cell degeneration in the rat hippocampus after trimethyltin administration.
• Three-dimensional observation of internal defects in semiconductor crystals by use of two-photon excitation.
• Three-repeat Tau 69 is a major tau isoform in laser-microdissected Pick bodies.
• Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study.
• [Case of jugular foramen schwannoma associated with tuberous sclerosis]
• [Electroencephalographic changes in sisters with infantile-onset dentatorubral-pallidoluysian atrophy (DRPLA)]
• [Left main trunk acute myocardial infarction]
• [Right coronary artery to left ventricle fistula associated with three-vessel coronary artery disease: a case report]