Expression of corticosteroid binding globulin in the rat central nervous system.

Expression of corticosteroid binding globulin in the rat central nervous system. Research Abstract Details 

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Expression of corticosteroid binding globulin in the rat central nervous system. Abstract Text:

G F Jirikowski,L Pusch,B ,Z Herbert,J D Caldwell,

Immunoreactivity for corticosteroid binding globulin was observed in the hypothalamus of intact male rats in the magnocellular nuclei and in single neurons in the periventricular nucleus and the lateral hypothalamus. The suprachiasmatic and the arcuate nuclei contained parvocellular neurons with specific immunoreactivity. Extensive networks of immunopositive fibers were observed in the lateral hypothalamus, the preoptic region, the bed nucleus of the stria terminalis and along the third ventricle. Immunostained axons often exhibited varicosities. The internal and the external layer of the median eminence showed numerous bundles of immunostained axons. Herring bodies in the posterior pituitary lobe contained specific immunoreactivity while pituicytes remained unstained. A portion of the Purkinje cells in the cerebellum and mossy fibers in the cerebellar granular layer stained for corticosteroid binding globulin. Some of the pyramidal cells in the hippocampus were corticosteroid binding globulin positive. Immunostained fibers occurred in the mesencephalon in the periaqueductal grey and in the medulla oblongata. A small fraction of the ependymal cells was also stained. In the spinal cord we observed specific immunoreactivity in a portion of the neurons in the dorsal horn. With polymerase chain reaction we confirmed the presence of the respective transcripts in the different brain regions. The multiple locations of corticosteroid binding globulin throughout the central nervous system suggest multiple functional properties, including neuroendocrine and neurohumoral functions.

Expression of corticosteroid binding globulin in the rat central nervous system. Publishing Authors By Initials

GF Jirikowski,L Pusch,B ,Z Herbert,JD Caldwell,

For similar proteins: blood proteins: serum globulins: alpha-globulins: transcortin research abstracts see: proteins: blood proteins: serum globulins: alpha-globulins: transcortin research

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Expression of corticosteroid binding globulin in the rat central nervous system. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of chemical neuroanatomy

VOLUME: 34

Page Numbers: 22-8

Journal Abbreviation: J. Chem. Neuroanat.

ISSN: 0891-0618

DAY: 31

MONTH: 03

YEAR: 2007

Expression of corticosteroid binding globulin in the rat central nervous system. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8902615

Expression of corticosteroid binding globulin in the rat central nervous system. Keywords Mesh Terms:

KEYWORDS: Transcortin

MESH TERMS: genetics

Chemical & Substance for Abstract: Expression of corticosteroid binding globulin in the rat central nervous system. Information

Substance Name: Transcortin

Registry Number: 9010-38-2

Grant and Affiliation Information for Expression of corticosteroid binding globulin in the rat central nervous system.

AFFILIATION: Department of Anatomy II, Friedrich Schiller Universität, Jena, Germany. gjir@mti.uni-jena.de

Country: Netherlands

AGENCY: United States NIMH

GRANT: R21 MH069810-01A1

ACRONYM: MH

MEDLINETA: J Chem Neuroanat

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