Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Abstract Text:

M Yamada,J P Revelli,G Eichele,M Barron,R J Schwartz,

Expression patterns of Tbx2, -3, and -5 genes were analyzed during chick embryonic heart development. Transcripts of these three cTbx genes were detected in overlapping patterns in the early cardiac crescent. cTbx2 and cTbx3 expression patterns closely overlapped with that of bmp2. cTbx5 expression diverged from cTbx2 and bmp2 during the elaboration and folding of the heart tube. In comparison, cTbx2 expression overlapped significantly with that of bmp2 and bmp4 during all stages of heart development and during later embryonic stages, suggestive of a specialized role for Tbx2 in septation. Coexpression of cTbx 2 and cTbx3 genes with bmp2 transcripts raised the possibility that these cTbx genes might be downstream bmp2 targets. Application of bmp2 selectively induced cTbx2 and cTbx3 expression in noncardiogenic embryonic tissue, and the bmp antagonist Noggin down-regulated cTbx2 gene activity. Moreover, the appearance of murine mTbx2 was blocked in bmp2 null mouse embryos. cTbx2 and to a lesser extent cTbx3 gene activity appears to be directed by BMPs during early cardiogenesis.

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Publishing Authors By Initials

M Yamada,JP Revelli,G Eichele,M Barron,RJ Schwartz,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental biology

VOLUME: 228

Page Numbers: 95-105

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 1

MONTH: Dec

YEAR: 2000

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.

AFFILIATION: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA.

Country: UNITED STATES

AGENCY: United States NHLBI

GRANT: P01 HL-49953

ACRONYM: HL

MEDLINETA: Dev Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2 Related Publications

• A dominant-negative p65 PAK peptide inhibits angiogenesis.
• After the war on terrorism, an attack on antibiotic resistance.
• Antiphase oscillation of the left and right suprachiasmatic nuclei.
• Changes in systolic blood pressure associated with lead in blood and bone.
• EDITORIAL: Globalization of Pediatrics.
• EDITORIAL:: Preparing for Future Amazement.
• Editorial.
• Editorial.
• Evaluation of 2 novel approaches for assessing the ability of demineralized freeze-dried bone allograft to induce new bone formation.
• Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli.
• Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2.
• In vivo DTI evaluation of white matter tracts in rat spinal cord.
• Integrative capacity of the caudal brainstem in the control of food intake.
• Lipid-lowering pharmacoeconomic studies. Reactor panel and open forum.
• MR Imaging and Epilepsy-3T or not 3T? That Is the Question.
• Monoclonal antibodies reveal lamB antigenic determinants on both faces of the Escherichia coli outer membrane.
• Monoclonal antibody as a probe for structure and function of an Escherichia coli outer membrane protein.
• Mutations that alter the transport function of the LamB protein in Escherichia coli.
• Nonadiabatic molecular dynamics simulations of correlated electrons in solution. 1. Full configuration interaction (CI) excited-state relaxation dynamics of hydrated dielectrons.
• Occupational health in Brazil.
• Phage lambda receptor (lamB protein) in Escherichia coli.
• Potential of porous poly-D,L-lactide-co-glycolide particles as a carrier for recombinant human bone morphogenetic protein-2 during osteoinduction in vivo.
• Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner.
• Reconsidering the early steps of protein secretion.
• Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation.
• The ISPOR Lipid Conference: Pharmacoeconomics and Outcomes Modeling Issues.
• The Suprachiasmatic Nucleus is a Functionally Heterogeneous Timekeeping Organ.
• Transition path sampling study of classical rate-promoting vibrations.
• Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus.
• p21-activated kinase regulates endothelial permeability through modulation of contractility.