[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.]

[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.] Research Abstract Details 

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[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.] Abstract Text:

Xing-jun Qin,Pan Qiu,Xu-kai Wang,Chang-fu Sun,Qing-chang Li,Yu-chen Han,Xiao-feng Guan,

PURPOSE: To investigate the expression and function of the adhesion molecules ICAM-3, CD34 and HLA-DR antigen on endothelial cells of hemangiomas in different stages. METHODS: SABC immunohistochemical technique was used to examine the expression of ICAM-3, CD34 and HLA-DR on vascular endothelial cells. Seventy-six specimens including 28 proliferating hemangiomas, 22 involuting hemangiomas, 18 vascular deformity and 8 normal skin tissue were obtained from infants and children for the experiment. RESULTS: The results showed: (1) both ICAM-3 and CD34 had high expression in proliferating hemangiomas, but poor or even no expression in involuting hemangiomas. There was a significant difference (P<0.001) between the two phases. Both ICAM-3 and CD34 had almost no expression in vascular deformity and normal skin tissue, significantly different from hemangiomas (P<0.001).(2) HLA-DR expression was closely related to the high differentiation phase of vascular epithelial cells. In the proliferating phase, HLA-DR didn't express, while it expressed highly as endothelial cells were in well-matured involuting phase. These differences were significant (P<0.001). CONCLUSION: ICAM-3 and CD34 might play a role in the early stage of angiogenesis and take part in the pathological genesis and regression process of hemangiomas by regulating endothelial cells adhesion; HLA-DR might be related either to acquisition of a mature phenotype or to an activated state of the endothelial cells.

[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.] Publishing Authors By Initials

XJ Qin,P Qiu,XK Wang,CF Sun,QC Li,YC Han,XF Guan,

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[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Shanghai kou qiang yi xue = Shanghai journal of st

VOLUME: 13

Page Numbers: 421-5

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ISSN: 1006-7248

DAY: 29

MONTH: Oct

YEAR: 2004

[Expression of cellular adhesion molecules and HLA-DR antigen on vascular endothelial cells in hemangiomas.] Information

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LANGUAGE: chi

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AFFILIATION: Department of Oral Maxillofacial Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. qinxj1989@sina.com

Country: China

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MEDLINETA: Shanghai Kou Qiang Yi Xue

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