Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants.

Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Research Abstract Details 

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Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Abstract Text:

Tae-Soo Kim,Ken Kojima,Akiko T Nishida,Kei Tashiro,Ji-Eun Lee,Kiyohiro Fujino,Takayuki Nakagawa,Yasushi Naito,Koichi Omori,Phillippe Lefebvre,Juichi Ito,

Severe damage by acoustic overstimulation or ototoxins induces inner ear hair cell loss, resulting in permanent hearing loss and balance disorders because hair cell regeneration scarcely occurs in the inner ear sensory organs of mammals. In this study, to evaluate the possibilities of cell transplantation therapy for damaged inner ear sensory organs, dissociated cell cultures of fetal otocyst cells (FOCs) were established from embryonic day 12.5 (E12.5) rat inner ears, and transplanted into gentamicin-treated explants of vestibular sensory epithelia. Two weeks after transplantation, immunohistochemical analysis demonstrated that some of the grafted FOCs survived within the vestibular sensory epithelia and expressed epitopes of calretinin. one of the hair cell marker proteins. These findings indicate that FOCs have the potential to migrate into damaged vestibular epithelia and differentiate into hair cell immunophenotypes. Cell transplantation therapy may be available for functional regeneration in inner ear diseases.

Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Publishing Authors By Initials

TS Kim,K Kojima,AT Nishida,K Tashiro,JE Lee,K Fujino,T Nakagawa,Y Naito,K Omori,P Lefebvre,J Ito,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 34-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Mar

YEAR: 2004

Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

Chemical & Substance for Abstract: Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants. Information

Substance Name: nestin

Registry Number: 0

Grant and Affiliation Information for Expression of calretinin by fetal otocyst cells after transplantation into damaged rat utricle explants.

AFFILIATION: Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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