Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration.

Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Research Abstract Details 

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Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Abstract Text:

Nina Goharkhay,Jing Lu,Juan C Felix,Deborah A Wing,Nina Goharkhay,Jing Lu,Juan C Felix,Deborah A Wing,

Our objective was to assess relative expression levels of mRNA for calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in various physiological states. Using semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), we analyzed myometrial samples from 46 women (10 menopausal, 10 nongravid premenopausal, 19 gravidae, and 7 premenopausal misoprostol-treated nongravid women) for the specific expression of CGRP-RCP mRNA. The expression of CGRP-RCP was significantly increased in gravid compared with nongravid myometrium ( P < 0.002). No significant differences in CGRP-RCP expression were found among the other study groups. We concluded that the increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility. Additional studies are necessary to evaluate the exact mechanism of action of CGRP and CGRP-RCP in human myometrium.

Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Publishing Authors By Initials

N Goharkhay,J Lu,JC Felix,DA Wing,N Goharkhay,J Lu,JC Felix,DA Wing,

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Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of perinatology

VOLUME: 24

Page Numbers: 497-500

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ISSN: 0735-1631

DAY: 12

MONTH: 09

YEAR: 2007

Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Information

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LANGUAGE: eng

NlmUniqueID: 8405212

Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Keywords Mesh Terms:

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Chemical & Substance for Abstract: Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration. Information

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Grant and Affiliation Information for Expression of calcitonin gene-related peptide-receptor component protein (CGRP-RCP) in human myometrium in differing physiological states and following misoprostol administration.

AFFILIATION: Department of Obstetrics and Gynecology, University of Texas Medical Branch Galveston, Galveston, TX 77555-0587, USA.

Country: United States

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MEDLINETA: Am J Perinatol

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