Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis.

Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Research Abstract Details 

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Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Abstract Text:

Jens J Kaden,Svetlana Bickelhaupt,Rainer Grobholz,Christian F Vahl,Siegfried Hagl,Martina Brueckmann,Karl K Haase,Carl-Erik Dempfle,Martin Borggrefe,

BACKGROUND AND AIM OF THE STUDY: Calcific aortic stenosis, the major heart valve disease encountered in the elderly, leads to massive calcium deposition in the valve leaflets that morphologically resembles bone formation. Recent studies have demonstrated the expression of various bone-associated proteins in stenotic valves, suggesting that valvular calcification may be an actively regulated process. Bone sialoprotein (BSP), a non-collagenous bone matrix protein, and bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor cytokine superfamily, are known to participate in the regulation of bone development and maturation. Their pathogenetic role in calcific aortic stenosis is unknown. METHODS: Using an immunoperoxidase technique and antibodies against BSP and BMP-2, the expression of BSP and BMP-2 was examined in 16 human aortic valves with calcific aortic stenosis obtained at valve replacement, and in seven normal autopsy controls without signs of aortic stenosis. RESULTS: By semiquantitative scoring, stenotic valves showed a significantly increased staining of BSP in cells and extracellular matrix as compared to control valves (2.7 +/- 0.1 versus 0.6 +/- 0.2 score units, p <0.001). Marked BMP-2 expression was detected in stenotic valves, mostly in cell-rich areas associated with focal calcium deposits, but no specific staining for BMP-2 was detected in control valves (1.5 +/- 0.2 versus 0.0 +/- 0.0 score units, p <0.001). CONCLUSION: These results demonstrate for the first time that BSP and BMP-2 are differentially expressed in normal aortic valves and in aortic stenosis, thereby supporting the concept that valvular calcification might be based on an actively regulated process involving BSP and BMP-2.

Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Publishing Authors By Initials

JJ Kaden,S Bickelhaupt,R Grobholz,CF Vahl,S Hagl,M Brueckmann,KK Haase,CE Dempfle,M Borggrefe,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of heart valve disease

VOLUME: 13

Page Numbers: 560-6

Journal Abbreviation: J. Heart Valve Dis.

ISSN: 0966-8519

DAY: 19

MONTH: Jul

YEAR: 2004

Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Information

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LANGUAGE: eng

NlmUniqueID: 9312096

Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis.

AFFILIATION: 1st Department of Medicine (Cardiology, Angiology, and Pneumology), University Hospital of Mannheim, Germany. jens.kaden@med.ma.uni-heidelberg.de

Country: England

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MEDLINETA: J Heart Valve Dis

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