Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury.

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Research Abstract Details 

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Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Abstract Text:

M Tanaka,S Endo,T Okuda,A N Economides,D M Valenzuela,A J Murphy,E Robertson,T Sakurai,A Fukatsu,G D Yancopoulos,T Kita,M Yanagita,M Tanaka,S Endo,T Okuda,A N Economides,D M Valenzuela,A J Murphy,E Robertson,T Sakurai,A Fukatsu,G D Yancopoulos,T Kita,M Yanagita,M Tanaka,S Endo,T Okuda,A N Economides,D M Valenzuela,A J Murphy,E Robertson,T Sakurai,A Fukatsu,G D Yancopoulos,T Kita,M Yanagita,

Once developed, end-stage renal disease cannot be reversed by any current therapy. Bone morphogenetic protein-7 (BMP-7), however, is a possible treatment for reversing end-stage renal disease. Previously, we showed that the BMP antagonist uterine sensitization-associated gene-1 (USAG-1, also known as ectodin and sclerostin domain-containing 1) negatively regulates the renoprotective action of BMP-7. Here, we show that the ratio between USAG-1 and BMP-7 expression increased dramatically in the later stage of kidney development, with USAG-1 expression overlapping BMP-7 only in differentiated distal tubules. Examination of USAG-1 expression in developing kidney indicated that a mosaic of proximal and distal tubule marker-positive cells reside side by side in the immature nephron. This suggests that each cell controls its own fate for becoming a proximal or distal tubule cell. In kidney injury models, the ratio of USAG-1 to BMP-7 expression decreased with kidney damage but increased after subsequent kidney regeneration. Our study suggests that USAG-1 expression in a kidney biopsy could be useful in predicting outcome.Kidney International (2008) 73, 181-191; doi:10.1038/sj.ki.5002626; published online 17 October 2007.

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Publishing Authors By Initials

M Tanaka,S Endo,T Okuda,AN Economides,DM Valenzuela,AJ Murphy,E Robertson,T Sakurai,A Fukatsu,GD Yancopoulos,T Kita,M Yanagita,M Tanaka,S Endo,T Okuda,AN Economides,DM Valenzuela,AJ Murphy,E Robertson,T Sakurai,A Fukatsu,GD Yancopoulos,T Kita,M Yanagita,M Tanaka,S Endo,T Okuda,AN Economides,DM Valenzuela,AJ Murphy,E Robertson,T Sakurai,A Fukatsu,GD Yancopoulos,T Kita,M Yanagita,

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Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Kidney international

VOLUME: 73

Page Numbers: 181-91

Journal Abbreviation: Kidney Int.

ISSN: 0085-2538

DAY: 17

MONTH: 10

YEAR: 2007

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Country: United States

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MEDLINETA: Kidney Int

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