Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis.

Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Research Abstract Details 

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Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Abstract Text:

We hypothesize that atopy is associated with a reduced T-cell function early in life and an imbalance in cytokine production. The purpose of this study was to investigate the expression of and responses to CD2 and CD3 in children who did or did not develop atopic dermatitis early in life. The expression of CD2 and CD3 was analyzed by flow cytometry, and proliferation of CD2 and CD3 was studied by 3H-thymidine incorporation in phytohaemagglutinin (PHA)- and anti-CD3-stimulated peripheral blood mononuclear cells (PBMC) of 18-month-old children, 25 with and 29 without atopic dermatitis. Exogenous interleukin (IL)-2 was added to compensate for possible functional differences in accessory cells. Anti-CD3-induced secretion of IL-4, IL-5, IL-6, IL-10, IL-13, and interferon-gamma (IFN-gamma) was analyzed by enzyme-linked immunosorbent assay (ELISA). Atopy was associated with a low proportion of CD2+ lymphocytes. Responsiveness to PHA, which activates lymphocytes partly via the sheep erythrocyte receptor, CD2, was reduced in the allergic children. The anti-CD3-induced proliferation declined more rapidly with antibody dilution in the allergic than in the non-allergic children. Atopic dermatitis was associated with high levels of anti-CD3-stimulated IL-5 secretion. The IL-4/IL-10 and IL-4/ITFN-gamma ratios were higher in children with elevated total immunoglobulin E (IgE) levels. Skin prick test-negative children with eczema produced higher levels of IL-10 than skin prick test-positive children. In conclusion, atopic children have a reduced T-cell function. Atopic dermatitis is associated with increased IL-5 production, while high total IgE levels are associated with high IL-4/IFN-gamma and IL-4/IL-10 ratios.

Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric allergy and immunology : official public

VOLUME: 11

Page Numbers: 175-82

Journal Abbreviation: Pediatr Allergy Immunol

ISSN: 0905-6157

DAY: 28

MONTH: Aug

YEAR: 2000

Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Information

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LANGUAGE: eng

NlmUniqueID: 9106718

Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Expression of and responses to CD2 and CD3 in 18-month-old children with and without atopic dermatitis.

AFFILIATION: Department of Health and Environment, Clinical Research Center, Faculty of Health Sciences, Linköping University, Sweden. Maria.Jenmalm@kfc.liu.se

Country: DENMARK

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MEDLINETA: Pediatr Allergy Immunol

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