Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium.

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Abstract Text:

Ezio Bettini,Frank L Margolis,Ezio Bettini,Frank L Margolis,

beta-Tubulin genes code for very similar proteins, sharing extensive identity in amino acid sequence within and across species, each of which manifests characteristic patterns of cell and tissue expression. While searching for olfactory specific mRNAs in the channel catfish (Ictalurus punctatus), we isolated a novel beta-tubulin cDNA. In the putative ORF, 1298 nucleotides were 80-88% identical to cloned cDNAs from zebrafish to human for beta-tubulin isotype IVb. This ORF is interrupted by an insert of 111 nucleotides located between the regions corresponding to exons 2 and 3 in other species. This insert lacks similarity to any sequence in the NCBI databases. We showed that this novel cDNA fragment hybridizes specifically to catfish olfactory epithelium mRNA on Northern analysis. Here we demonstrate by in situ analysis of catfish olfactory epithelium that the expression of this mRNA is spatially restricted to the outer two-thirds of each olfactory lamella where olfactory receptor neurons reside. These results suggest that this nucleotide sequence is the result of incomplete RNA transcript processing. The growing awareness of the regulatory roles played by RNAs transcribed from intronic regions of genes suggests that this observation may have relevance to regulation of gene expression in olfactory tissue during development and axon targeting.

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Publishing Authors By Initials

E Bettini,FL Margolis,E Bettini,FL Margolis,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of molecular histology

VOLUME: 38

Page Numbers: 571-9

Journal Abbreviation: J. Mol. Histol.

ISSN: 1567-2379

DAY: 12

MONTH: 09

YEAR: 2007

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101193653

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium.

AFFILIATION: Department of Anatomy and Neurobiology, School of Medicine, University of Maryland, HSF 2, 20 Penn Street, Baltimore, MD, 21210, USA, fmargoli@umaryland.edu.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Mol Histol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium Related Publications

• "Steel wool keratopathy": a clinical sign of chronic inflammation.
• A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.
• A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array.
• Apical junctional complexes and cell polarity.
• Bex1 knock out mice show altered skeletal muscle regeneration.
• Body dysmorphic disorder symptoms among patients with acne vulgaris.
• Confronting proviral HIV infection.
• Digital imaging of wounds: are measurements reproducible among observers?
• Effect of fluoride on artificial caries lesion progression and repair in human enamel: regulation of mineral deposition and dissolution under in vivo-like conditions.
• Emergency medical services education: past, present, and future.
• Expression of an intron-containing beta-tubulin mRNA in catfish olfactory epithelium.
• Hepatitis B vaccination of men who have sex with men attending an urban STD clinic: impact of an ongoing vaccination program, 1998-2003.
• Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci.
• Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: a prospective study by AIDS Clinical Trials Group 5170.
• Mammalian lin-7 stabilizes polarity protein complexes.
• Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
• Nuclear receptors and bone.
• Obituary: arun fotedar.
• Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons.
• PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.
• Radiation therapy for cutaneous squamous cell carcinoma involving the parotid area lymph nodes: dose and volume considerations.
• Repeat expansion and autosomal dominant neurodegenerative disorders: consensus and controversy.
• Restricted-carbohydrate diets in patients with type 2 diabetes: a meta-analysis.
• Sensate scaffolds coupled to telemetry can monitor in vivo loading from within a joint over extended periods of time.
• Sodium/calcium exchanger expression in the mouse and rat olfactory systems.
• Spindle cell lipoma of the mediastinum: a differential consideration for liposarcoma.
• The prevalence of atopic triad in children with physician-confirmed atopic dermatitis.
• Upper respiratory tract infection in household contacts of acne patients.
• c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.
• pH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro.