Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma.

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Abstract Text:

M I Filipe,J M Linehan,L G Durrant,M R Price,N C Smeeton,S Pathak,D M Swallow,

Previous histochemical studies have shown that changes occur in the composition of mucins both in preneoplastic and neoplastic lesions of the gastric mucosa. Since monoclonal antibodies are now available which recognize the protein product of distinct mucin genes, they are likely to provide useful tools for evaluating these changes. Thus, a monoclonal antibody 996/1 raised against a peptide epitope of the colonic mucin MUC2 was examined for its potential as a prognostic indicator in gastric cancer. 996/1 works well on formalin-fixed paraffin sections and shows good staining of the colonic goblet cells in the region of the golgi, while there is no staining of normal control gastric mucosa. The epitope was detected in all cases of intestinal metaplasia (44 samples) and some but not all cases of dysplasia (26 samples) and gastric carcinoma (74 samples). There was no significant difference between the positivity of the tumours according to their classification, stage and lymph node status. These results unfortunately gave little indication that this antibody would be a useful prognostic tool in gastric cancer. However, the pattern of 996/1 staining provides useful information about the molecular changes in mucin expression that occur in gastric carcinogenesis.

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Publishing Authors By Initials

MI Filipe,JM Linehan,LG Durrant,MR Price,NC Smeeton,S Pathak,DM Swallow,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

PUBMED ID PMID:

MEDLINE DATE:

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of cancer prevention : the offici

VOLUME: 5

Page Numbers: 287-95

Journal Abbreviation: Eur. J. Cancer Prev.

ISSN: 0959-8278

DAY: 30

MONTH: Aug

YEAR: 1996

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9300837

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: immunology

Chemical & Substance for Abstract: Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma.

AFFILIATION: Department of Histopathology, UMDS, Guy's Hospital, London, UK.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Cancer Prev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma Related Publications

• A new emulsifying wax.
• Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5.
• Alumina catalysts for vapour-phase organic dehydrations, deaminations, etc.
• Antiviral agents 1978-1983.
• Antiviral agents.
• Compression of coeliac axis.
• DISCOLORATION OF PRIMARY DENTITION AFTER MATERNAL TETRACYCLINE INGESTION IN PREGNANCY.
• Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma.
• Free flight maneuvers of stalk-eyed flies: do eye-stalks affect aerial turning behavior?
• Gastrointestinal stromal tumours: Etiology, pathology and clinical management.
• Hypokalemia after treatment with duogastrone (carbenoxolone).
• Letter: Hypertension--which arm?
• Multiple transcripts of MUC3: evidence for two genes, MUC3A and MUC3B.
• New monoclonal antibodies to non-glycosylated domains of the secreted mucins MUC5B and MUC7.
• Outcomes of salvage surgery for squamous cell carcinoma of the anal canal.
• Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia.
• Polymorphism of human mucin genes in chest disease: possible significance of MUC2.
• Recent progress in the management of retroperitoneal sarcoma.
• Selection for aerobic capacity affects corticosterone, monoamines and wheel-running activity.
• Surgeons' knowledge of quality indicators for gastric cancer surgery.
• The ESR detection of irradiated food.
• The ideal dentist.
• The image of the dentist.
• [The role of the dentist in the care of handicapped children]