Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds.

Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Research Abstract Details 

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Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Abstract Text:

K Kitajima,U Koshimizu,T Nakamura,

PB-cadherin is a novel classic type of cadherin predominantly expressed in brain of adult rats (Sugimoto et al. [1996] J. Biol. Chem. 271:11548-11556). To examine the spatial and temporal expression of PB-cadherin during development, we isolated full-length cDNA of mouse PB-cadherin and studied its expression pattern in mouse embryos. In Northern blots, PB-cadherin mRNA was detected at 9.5 days postcoitum (dpc) onwards. Whole-mount in situ hybridization showed that PB-cadherin signals mainly occurred in developing neural tissues, including brain and spinal cord, and limb buds in the 10.5 dpc embryo. In the brain, PB-cadherin mRNA were strongly expressed in the forebrain and midbrain-hindbrain boundary region (isthmus). In isthmus, PB-cadherin expression delineated the expression area of Wnt-1, a secreted signaling molecule essential for proper cerebellum development. In the developing limb, PB-cadherin mRNA was first localized in posterior part of buds at 10.5 dpc, and was thereafter distributed in a domain around the digit rudiments. This expression pattern is similar to that of BMP-2, a secreted signalling molecule involving limb patterning and morphogenesis. These findings suggested the possibility that PB-cadherin-mediated cell-cell adhesion has a functional role in pattern formation and morphogenesis of mouse embryonic brain and limb. Dev Dyn 1999;215:206-214.

Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Publishing Authors By Initials

K Kitajima,U Koshimizu,T Nakamura,

For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

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Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 215

Page Numbers: 206-14

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 19

MONTH: Jul

YEAR: 1999

Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Keywords Mesh Terms:

KEYWORDS: Zebrafish Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds.

AFFILIATION: Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Osaka, Japan.

Country: UNITED STATES

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MEDLINETA: Dev Dyn

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