Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy.

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Abstract Text:

Ombretta Turriziani,Nicola Gianotti,Francesca Falasca,Arianna Boni,Anna Rita Vestri,Alice Zoccoli,Adriano Lazzarin,Guido Antonelli,

The aim of the study was to evaluate the mRNA expression of four relevant ABC-transporter genes [MDR1 (P-glycoprotein; Pgp), MRP1, MRP4, and MRP5] in HIV-positive individuals failing treatment and analyze the association between the levels of their expression and viral load, CD4 cell count, and therapeutic history. Ninety-eight HIV-positive samples and 20 samples from healthy donors were analyzed, retrospectively. Peripheral blood mononuclear cells (PBMCs) from HIV1-positive individuals were collected at the time of virological failure. Expression of mRNA of Pgp, MRP1, MRP4, and MRP5 in PBMCs was evaluated by real-time PCR. A high inter-individual variability was observed in both HIV-positive individuals and healthy donors but the expression levels of all mRNA analyzed were significantly higher in the HIV-infected group (P < 0.05). A weak but significant inverse correlation was observed between CD4 cell counts and expression levels of MRP4 and MRP5. Comparison of mRNA expression between individuals with different therapeutic histories showed that expression of MRP4 and MRP5 genes in patients who were both protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI)-experienced was significantly higher than in patients who were PI experienced but NNRTI-naïve. In conclusion, the mRNA expression of Pgp, MRP1, MRP4, and MRP5 varies among HIV-infected patients and healthy donors but is significantly higher in HIV-positive patients than in donors. The expression of MRP4 and MRP5 seems to correlate with CD4 cell counts. The same protein seems to be overexpressed in patients receiving NNRTIs. J. Med. Virol. 80:766-771, 2008. (c) 2008 Wiley-Liss, Inc.

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Publishing Authors By Initials

O Turriziani,N Gianotti,F Falasca,A Boni,AR Vestri,A Zoccoli,A Lazzarin,G Antonelli,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical virology

VOLUME: 80

Page Numbers: 766-71

Journal Abbreviation: J. Med. Virol.

ISSN: 0146-6615

DAY: 2

MONTH: May

YEAR: 2008

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7705876

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy.

AFFILIATION: Department of Experimental Medicine, Virology Section, "Sapienza", University of Rome, Rome, Italy.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Med Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy Related Publications

• 1-Hexene Isomerization over Sulfated Mesoporous Ta Oxide: The Effects of Active Site and Confinement.
• Carotid integrated backscatter analysis in patients with subclinical hypothyroidism.
• Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism.
• Crisis in health care.
• Determinants of reduced interferon gamma expression in severe respiratory syncytial virus disease: the authors respond.
• Electric response audiometry in infants and preschool children. Long-term control of the results.
• Enteric glial cells and their role in gastrointestinal motor abnormalities: introducing the neuro-gliopathies.
• Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy.
• Functional hemodynamic monitoring and dynamic indices of fluid responsiveness.
• H2 Storage Materials (22KJ/mol) Using Organometallic Ti Fragments as sigma-H2 Binding Sites.
• Hepatobiliary involvement in adolescents and adults with cystic fibrosis.
• Higher level phylogeny and evolutionary trends in Campanulaceae subfam. Lobelioideae: Molecular signal overshadows morphology.
• Hydrogen storage in mesoporous titanium oxide-alkali fulleride composites.
• Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides.
• Modeling equilibrium concentrations of Bjerrum and molecular point defects and their complexes in ice I(h).
• Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study.
• On the trapping of Bjerrum defects in ice Ih: the case of the molecular vacancy.
• Optical underwater acoustic sensor.
• Pharmacodynamics of peginterferon alpha-2a and peginterferon alpha-2b in interferon-naïve patients with chronic hepatitis C: a randomized, controlled study.
• Study of the genotypic resistant pattern in HIV-infected women and children from rural west Cameroon.
• Sulfated and phosphated mesoporous Nb oxide in the benzylation of anisole and toluene by benzyl alcohol.
• Sulfated mesoporous tantalum oxides in the shape selective synthesis of linear alkyl benzene.
• The CK1 gene family: expression patterning in zebrafish development.
• The Rebif new formulation story: it's not trials and error.
• Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis.
• [Anginal syndrome caused by lung cancer.]
• [Emotional hyperglycemia caused by hospitalization]
• [Maximum sterno-chondro-epigastrico inspiratory retraction in the terminal stage of multiple myeloma]
• [Rheumatic neuroses; psychosomatic aspects of psychogenic or functional rheumatism.]
• [Ultrasonographic study of renal cystic disease]