Expression and suppression of human telomerase RNA.

Expression and suppression of human telomerase RNA. Research Abstract Details 

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Expression and suppression of human telomerase RNA. Abstract Text:

S Li,E H Blackburn,

Telomeres are maintained by the ribonucleoprotein (RNP) enzyme telomerase, which replenishes telomeres through its unique mechanism of internal RNA-templated addition of telomeric DNA. Telomerase is active in most human cancers, typically because its core protein subunit, TERT, is up-regulated. Although the major known function of telomerase in cancer is to replenish telomeric DNA and maintain cell immortality, the regulation of the RNA component of telomerase is not well understood. In the course of investigations that have implicated telomerase RNA in key aspects of cancer progression, including metastasis, we explored some of the cis-acting elements affecting telomerase RNA expression and knockdown. The expression efficiency and subsequent RNA processing to produce the mature hTER differed considerably among various promoters. Together with other results, these findings establish that the crucial elements of the hTER gene affecting RNA-processing efficiency to produce the mature hTER RNA are the promoter and internal telomerase RNA-coding sequences.

Expression and suppression of human telomerase RNA. Publishing Authors By Initials

S Li,EH Blackburn,

For similar chromosome structures: telomere research abstracts see: chromosome structures: telomere research

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Expression and suppression of human telomerase RNA. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cold Spring Harbor symposia on quantitative biolog

VOLUME: 71

Page Numbers: 211-5

Journal Abbreviation: Cold Spring Harb. Symp. Quant.

ISSN: 0091-7451

DAY: 3

MONTH: 12

YEAR: 2006

Expression and suppression of human telomerase RNA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1256107

Expression and suppression of human telomerase RNA. Keywords Mesh Terms:

KEYWORDS: Telomere

MESH TERMS: metabolism

Chemical & Substance for Abstract: Expression and suppression of human telomerase RNA. Information

Substance Name: Telomerase

Registry Number: EC 2.7.7.49

Grant and Affiliation Information for Expression and suppression of human telomerase RNA.

AFFILIATION: Department of Biochemistry and Biophysics, University of California, San Fransisco, California 94158-2517, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA96840

ACRONYM: CA

MEDLINETA: Cold Spring Harb Symp Quant Bi

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