[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue]

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Abstract Text:

Rui-Yun Peng,Ya-Bing Gao,De-Wen Wang,Xing-Yi Xiao,Hao-Yu Chen,Xiao-Hong Wu,Jie Liu,Long-He Xu,Wen-Hua Hu,

AIM: To explore the expression and significance of enkephalin and dopamine in rat cerebral concussion tissue. METHODS: 80 Wistar male rats were used to make animal model of cerebral concussion, which were sacrificed on 1,3,7,14 and 30 days after postconcussion and the brain tissues were taken out. The expression patterns of enkephalin and dopamine were studied in the course of cerebral concussion by immunohistochemical staining. RESULTS: The clinical manifestation with typical cerebral concussion character was seen in rat group with 100 g body weight. The mainly pathologic changes were cerebral vascular constriction and dilatation, congestion and edema of cerebral tissue, and neuronal degeneration and necrosis. Expression of enkephalin was increased on day 1 after injury and the enkephalin positive area was in the plasma of endothelial cells in cerebral cortex, hippocamp and cerebellum. The expression of enkephalin reached the peak on day 7 after injury, and the positive area was also seen in the plasma of neurons in cerebral cortex, hippocamp and cerebellum. From 14 days after injury, the expression of enkephalin decreased gradually, but until 30 days after injury it was still higher than that of controls. Expression of dopamine increased in 7 days after injury and the positive area was seen in the plasma of endothelial cells and in the vessel wall in cerebral cortex, hippocamp, thalamus and cerebellum, and had no notable changes at other time points. CONCLUSION: The mainly pathologic changes after cerebral concussion were blood circulatory disorder and denaturation and necrosis of parenchymal cells. Enkephalin and dopamine may participate in the pathophysiological course of cerebral injury after cerebral concussion, and play an important role in the blood vessel injury, regulation of blood-brain barrier and the denaturation and necrosis of nerve cells.

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Publishing Authors By Initials

RY Peng,YB Gao,DW Wang,XY Xiao,HY Chen,XH Wu,J Liu,LH Xu,WH Hu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese jour

VOLUME: 19

Page Numbers: 232-4

Journal Abbreviation: Xi Bao Yu Fen Zi Mian Yi Xue Z

ISSN: 1007-8738

DAY: 24

MONTH: May

YEAR: 2003

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 101139110

[Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue]

AFFILIATION: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850,China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Xi Bao Yu Fen Zi Mian Yi Xue Z

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue Related Publications

• A study of rubella virus infection during pregnancy.
• Inhibitory effect of adrenomedullin on L-type calcium currents in guinea-pig ventricular myocytes.
• The effect of para-aminobenzoic acid on growth and metabolism of Porphyromonas gingivalis.
• [A conjunctival pulling-back technique for treatment of serious symblepharon]
• [A preliminary study on body level of nitric oxide in workers exposed to carbon disulfide]
• [Application of digital subtraction angiography and type B ultrasonography in the evaluation of vascular injury in patients with high voltage electrical injury]
• [Changes in electrophysiological and morphological properties of neurons during the development of the visual cortex in the rat]
• [Clinical observation of the curative effect of Qiangxin Mixture on congestive heart failure]
• [Clinical observation of the pathological changes of axial length, corneal curvature and posterior segment wall of eyeball in eyes with high myopia]
• [Clinical study in prophylactic use of chinese medicine to prevent chemoradiotherapy induced mucositis in nasopharyngeal carcinoma]
• [Comparison of perioperative myocardial enzyme changes among congenital, rheumatic and coronary artery diseases]
• [Development of impact acceleration measurement facility in return-cabin of spacecraft]
• [Effect of nitroquine on the membrane phospholipid of intraerythrocytic Plasmodium yoelii in vitro]
• [Evaluation of urinary ortho-cresol as biological monitoring indicator of occupational exposure to toluene]
• [Experimental study of myocardial protective effect of cardiac arrest versus beating heart during open heart surgery]
• [Exploring the possibility of a relationship between polymorphism in TIM-1 and allergic asthma in children of the Hans from Hubei province of China]
• [Expression and significance of enkephalin and dopamine in experimental rat cerebral concussion tissue]
• [Expression of amino terminal of nucleoprotein and glycoprotein G2 of Hantaan virus in insect cells in the form of fusion protein]
• [In vivo endochondral bone formation by implanting human bone morphogenetic protein-2-producing fibroblasts into nude mouse muscle]
• [Invasive rhinocerebral aspergillosis occurred during myelosuppressive phase after chemotherapy: a case report and literature review]
• [Labia minora skin flap vaginoplasty using tissue expansion]
• [Make efforts to improve the level of rescue and treatment of pediatric patients with septic shock]
• [Pathogenetic characteristics and therapeutic approaches of aplastic anemia]
• [Proceedings on the toxicity of a new hydroxylammonium nitrate (HAN)-based liquid propellant]
• [Recent progress of liquid resuscitation on severe trauma shock]
• [Significance of soluble intercellular adhesion molecule-1 and procalcitonin in diagnosis of neonatal septicemia]
• [Studies on the dynamic trends of diosgenin content in vegetative organs of Dioscorea zingiberensis]
• [Study of antibody enzyme with acetylcholonesteraseactivity]
• [The expression of MMP-9, MMP-2 in the remodeling bone tissue around implant during unloaded period]
• [The research progress of using electroporation therapy in treatment of tumor]