Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C).

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Abstract Text:

Vikki M Abrahams,Todd M Schaefer,John V Fahey,Irene Visintin,Jacqueline A Wright,Paulomi B Aldo,Roberto Romero,Charles R Wira,Gil Mor,

BACKGROUND: During pregnancy, the placenta may become exposed to micro-organisms, such as viruses, which may pose a substantial threat to the embryo/fetus well-being. Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs). METHODS: The objective of this study was to determine whether the engagement of TLR-3 with viral dsRNA by first-trimester trophoblast could induce the production of factors necessary to generate an antiviral response. Therefore, trophoblast cells were exposed to the TLR-3 agonist, Poly(I : C). RESULTS: We report that following stimulation with Poly(I : C), first-trimester trophoblast cells produce interferon beta (IFNbeta) and secretory leukocyte protease inhibitor (SLPI), as well as the intracellular factors 2',5'-oligoadenylate synthetase (OAS), Myxovirus-resistance A (MxA) and apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G). This response is TLR-3 specific because the TLR-4 ligand, lipopolysaccharide (LPS), had no effect on the production of these antimicrobial factors. Furthermore, we describe a positive feedback mechanism in which IFNbeta enhances the antiviral response by promoting the production of OAS, MxA and APOBEC3G. CONCLUSIONS: These findings suggest that trophoblast cells are able to recognize and specifically respond to viral products in a highly regulated fashion and that the placenta may be pivotal in the control of viral infections at the maternal-fetal interface.

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Publishing Authors By Initials

VM Abrahams,TM Schaefer,JV Fahey,I Visintin,JA Wright,PB Aldo,R Romero,CR Wira,G Mor,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Human reproduction (Oxford, England)

VOLUME: 21

Page Numbers: 2432-9

Journal Abbreviation:

ISSN: 0268-1161

DAY: 3

MONTH: 06

YEAR: 2006

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701199

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C). Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C).

AFFILIATION: Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hum Reprod

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, PolyI : C Related Publications

• Balancing regulatory controls and incentives: toward smarter and more transparent oversight in long-term care.
• Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells.
• Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines.
• Decisions to forgo hospitalization in advanced dementia: a nationwide study.
• Defining and measuring quality outcomes in long-term care.
• Defining and measuring quality outcomes in long-term care.
• Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection.
• Diagnostic markers for early detection of ovarian cancer.
• Dysfunctional implications of narrow window theory: variability in the intuitive assessment of correlation.
• Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C).
• First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis.
• Government expenditures at the end of life for short- and long-stay nursing home residents: differences by hospice enrollment status.
• Hospice Effect on Government Expenditures among Nursing Home Residents.
• Hospitalization of nursing home residents with cognitive impairments: the influence of organizational features and state policies.
• Hospitalization of nursing home residents: the effects of states' Medicaid payment and bed-hold policies.
• In vitro discriminative antipseudomonal properties resulting from acyl substitution of N-terminal sequence of dermaseptin s4 derivatives.
• Is dementia special care really special? A new look at an old question.
• Long-term care market competition and nursing home dementia special care units.
• Medicaid payment rates, case-mix reimbursement, and nursing home staffing--1996-2004.
• MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer.
• Pediatric transperitoneal laparoscopic partial nephrectomy: comparison with an age-matched group undergoing open surgery.
• Phenoxodiol-Topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects.
• Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath.
• Quantum key distribution with classical Bob.
• Studies on denitrification. VII. Further purification and properties of denitrifying enzyme.
• Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor.
• Translational control of recombinant human acetylcholinesterase accumulation in plants.
• Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy.
• X-linked inhibitor of apoptosis (XIAP) confers human trophoblast cell resistance to Fas-mediated apoptosis.
• [Not Available.]