Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis.

Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Research Abstract Details 

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Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Abstract Text:

Andrew J Lepisto,Min Xu,Hideo Yagita,Andrew D Weinberg,Robert L Hendricks,

Herpes stromal keratitis (HSK) is an immunopathological disease regulated by Th1 CD4 T cells, which require APC and costimulation within the infected cornea to mediate disease. Recent studies suggest the OX40:OX40 ligand (OX40L) interaction enhances effector cell cytokine secretion at inflammatory sites. OX40(+) cells were detected in HSV-1-infected mouse corneas as early as 3 days postinfection (dpi), prior to the onset of HSK, and their frequency increased through 15 dpi, when all mice exhibited severe HSK. OX40L(+) cells were first detected at 7 dpi, coincident with the initiation of HSK. It is interesting that the OX40L(+) cells did not coexpress MHC Class II or the dendritic cell (DC) marker CD11c. Our findings demonstrate rapid infiltration of activated (OX40(+)) CD4(+) T cells into HSV-1-infected corneas and expression of OX40L on MHC Class II-negative cells but surprisingly, not on MHC Class II(+) CD11c(+) DC, which are present in the infected corneas and required for HSK. Moreover, neither local nor systemic treatment of mice with a blocking antibody to OX40L or with a blocking fusion protein altered the course of HSK significantly, possibly as a result of a lack of OX40L expression on functional APC.

Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Publishing Authors By Initials

AJ Lepisto,M Xu,H Yagita,AD Weinberg,RL Hendricks,

For similar peptides: intercellular signaling peptides and proteins: cytokines: tumor necrosis factors research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: tumor necrosis factors research

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Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of leukocyte biology

VOLUME: 81

Page Numbers: 766-74

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 21

MONTH: 12

YEAR: 2006

Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Information

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LANGUAGE: eng

NlmUniqueID: 8405628

Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. Information

Substance Name: Tumor Necrosis Factors

Registry Number: 0

Grant and Affiliation Information for Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis.

AFFILIATION: Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01 EY010359

ACRONYM: EY

MEDLINETA: J Leukoc Biol

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