Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Abstract Text:

The LIM homeobox containing genes of the LIM-3 group, Lhx3 and Lhx4, are critical for normal development. Both genes are involved in the formation of the pituitary and the motoneuron system and loss of either gene causes perinatal lethality. Previous studies had shown that Lhx3 is overexpressed in hyperplastic placentas of mouse interspecies hybrids. To determine the role of LHX3 in the mouse placenta, we performed expression and function analyses. Our results show that Lhx3 exhibits specific spatial and temporal expression in the mouse placenta. However, deletion of Lhx3 does not produce a placental phenotype. To test whether this is due to functional substitution by Lhx4, we performed a phenotype analysis of Lhx3-/-; Lhx4-/- double-mutant placentas. A subset of Lhx3-/-; Lhx4-/- placentas exhibited abnormal structure of the labyrinth. However, absence of both LIM-3 genes did not interfere with placental transport nor consistently with expression of target genes such as Gnrhr. Thus, LHX3 and LHX4 appear to be dispensable for placental development and function. Developmental Dynamics 237:1517-1525, 2008. (c) 2008 Wiley-Liss, Inc.

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental dynamics : an official publication o

VOLUME: 237

Page Numbers: 1517-25

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 30

MONTH: May

YEAR: 2008

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.

AFFILIATION: Department of Animal Genetics and Development, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dev Dyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta Related Publications

• Carboxypeptidase E in the mouse placenta.
• Expression and function of the LIM homeobox containing genes Lhx3 and Lhx4 in the mouse placenta.
• Influence of murine maternal diabetes on placental morphology, gene expression, and function.