Exploring functional genomics for the development of novel intervention strategies against tuberculosis.

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Abstract Text:

Helmy Rachman,Stefan H E Kaufmann,Helmy Rachman,Stefan H E Kaufmann,

Tuberculosis (TB) remains a serious threat to humankind, and humans have encountered the causative agent of TB, Mycobacterium tuberculosis (MTB), for more than 10,000 years. Despite rapid advances in technology, efforts to besiege this robust pathogen seem to fail. The availability of genome sequences of several MTB complex strains open a new era of MTB research, the functional genomics, which will provide guidelines for novel control measures. In recent years, a series of methods have been developed to explore the mechanisms employed by MTB to persist and cause disease in the host. DNA array technology enables us to perform comparative genomics of different MTB strains and to examine the gene expression profiles of MTB growing under diverse living conditions. The generated transcriptome data can be exploited for design of new drugs, especially against multidrug-resistant (MDR) strains, development of more efficient vaccines, and identification of biomarkers for better diagnosis.

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Publishing Authors By Initials

H Rachman,SH Kaufmann,H Rachman,SH Kaufmann,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of medical microbiology : IJ

VOLUME: 297

Page Numbers: 559-67

Journal Abbreviation: Int. J. Med. Microbiol.

ISSN: 1438-4221

DAY: 27

MONTH: 04

YEAR: 2007

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100898849

Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Exploring functional genomics for the development of novel intervention strategies against tuberculosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Exploring functional genomics for the development of novel intervention strategies against tuberculosis.

AFFILIATION: Department of Immunology, Max Planck Institute for Infection Biology, Schumannstr. 21/22, D-10117 Berlin, Germany.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Med Microbiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Exploring functional genomics for the development of novel intervention strategies against tuberculosis Related Publications

• Absolute quantification of myocardial blood flow with 13N-ammonia and 3-dimensional PET.
• Accuracy of 64-slice CT angiography for the detection of functionally relevant coronary stenoses as assessed with myocardial perfusion SPECT.
• Added value of coronary artery calcium score as an adjunct to gated SPECT for the evaluation of coronary artery disease in an intermediate-risk population.
• Apoptosis in the treatment of cancer: a promise kept?
• Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities.
• Caviomorph placentation as a model for trophoblast invasion.
• Dangerous entanglements.
• Epibatidine alkaloid chemistry: 5. Domino-Heck reactions of azabicyclic and tricyclic systems.
• Exploring functional genomics for the development of novel intervention strategies against tuberculosis.
• Expression of membrane-type 5 matrix metalloproteinase in human endometrium and endometriosis.
• Febrile ulceronecrotic lymphomatoid papulosis.
• Hearing facial identities.
• In search of induction and latency periods: space-time interaction accounting for residential mobility, risk factors and covariates.
• Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.
• Initiating the uninitiated: replication of damaged DNA and carcinogenesis.
• Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.
• Persistence of peri-neural granulomas after successful treatment of leprosy.
• Pollakisuria in a dwarf goat due to pathologic enlargement of the uterus.
• Regional IFNgamma expression is insufficient for efficacious control of food-borne bacterial pathogens at the gut epithelial barrier.
• Role of NF2 haploinsufficiency in NF2-associated polyneuropathy.
• Social approach and autistic behavior in children with fragile X syndrome.
• The changing natural history of spinal muscular atrophy type 1.
• The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.
• Tuberculosis and AIDS - a devilish liaison.
• [Cutaneous botryomycosis : A rarely diagnosed bacterial infection of the skin.]
• [Herd problem: udder health--a retrospective study of farms with udder health problems assessed by the Swiss Bovine Health Service (BHS) from 1999 to 2004]
• [In Process Citation]
• [Orthostatic intolerance and syncope]
• [Postoperative pyoderma gangrenosum of Cullen.]
• [The most common dysautonomias]