Exploitation of bile acid transport systems in prodrug design.

Exploitation of bile acid transport systems in prodrug design. Research Abstract Details 

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Exploitation of bile acid transport systems in prodrug design. Abstract Text:

Elina ,

The enterohepatic circulation of bile acids is one of the most efficient recycling routes in the human body. It is a complex process involving numerous transport proteins, which serve to transport bile acids from the small intestine into portal circulation, from the portal circulation into the hepatocyte, from the hepatocyte into the bile, and from the gall bladder to the small intestine. The tremendous transport capacity and organ specificity of enterohepatic circulation combined with versatile derivatization possibilities, rigid steroidal backbone, enantiomeric purity, availability, and low cost have made bile acids attractive tools in designing pharmacological hybrid molecules and prodrugs with the view of improving intestinal absorption, increasing the metabolic stability of pharmaceuticals, specifically targeting drugs to organs involved in enterohepatic circulation, as well as sustaining therapeutically reasonable systemic concentrations of active agents. This article briefly describes bile acid transport proteins involved in enterohepatic circulation, summarizes the key factors affecting on the transport by these proteins, and reviews the use of bile acids and their derivatives in designing prodrugs capable of exploiting the bile acid transport system.

Exploitation of bile acid transport systems in prodrug design. Publishing Authors By Initials

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For similar proteins research abstracts see: proteins research

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Exploitation of bile acid transport systems in prodrug design. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecules (Basel, Switzerland)

VOLUME: 12

Page Numbers: 1859-89

Journal Abbreviation:

ISSN: 1420-3049

DAY: 16

MONTH: 08

YEAR: 2007

Exploitation of bile acid transport systems in prodrug design. Information

Number of References: 161

LANGUAGE: eng

NlmUniqueID: 100964009

Exploitation of bile acid transport systems in prodrug design. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Exploitation of bile acid transport systems in prodrug design. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Exploitation of bile acid transport systems in prodrug design.

AFFILIATION: University of Jyväskylä, Department of Chemistry, P.O. Box 35, FIN-40014 University of Jyväskylä, Finland. elvirtan@cc.jyu.fi

Country: Switzerland

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MEDLINETA: Molecules

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