[Experimental study on osteoinduction of coral composited artificial bone]

[Experimental study on osteoinduction of coral composited artificial bone] Research Abstract Details 

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[Experimental study on osteoinduction of coral composited artificial bone] Abstract Text:

S L Zhang,Z Y Meng,T Q Mao,

OBJECTIVE: To improve the osteoinduction of coral and provide a perfect bone graft substitute for clinical bone defects. METHODS: By combining coral with collagen and recombinant human bone morphogenetic protein-2(rhBMP-2), coral/collagen/rhBMP-2 composite was obtained. The composite was implanted into the back muscle pouches of mice, and coral/collagen or coral/rhBMP-2 were implanted as control. The osteoinduction of the composite was assessed by histology and image analysis system. RESULTS: The chondrocyte differentiation and matrix formation were observed in local sites after one week, lamellar bone with bone marrow were formed after 4 weeks, and coral were absorbed partially. The quantity of osteoinduction was time-related and rhBMP-2 dose-related(P < 0.01). Coral/collagen and coral/rhBMP-2 implants did not show any bone or cartilage formation. CONCLUSION: The coral/collagen/rhBMP-2 composite possesses a superior osteoinduction and will be a new type of bone substitute to be used in orthopedic and maxillofacial surgery.

[Experimental study on osteoinduction of coral composited artificial bone] Publishing Authors By Initials

SL Zhang,ZY Meng,TQ Mao,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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MEDLINE DATE:

[Experimental study on osteoinduction of coral composited artificial bone] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhonggu

VOLUME: 13

Page Numbers: 141-4

Journal Abbreviation:

ISSN: 1002-1892

DAY: 19

MONTH: May

YEAR: 1999

[Experimental study on osteoinduction of coral composited artificial bone] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 9425194

[Experimental study on osteoinduction of coral composited artificial bone] Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: [Experimental study on osteoinduction of coral composited artificial bone] Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for [Experimental study on osteoinduction of coral composited artificial bone]

AFFILIATION: Department of Stomatology, Nanjing Hospital of PLA, Nanjing, Jiangsu, P. R. China 210002.

Country: China

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MEDLINETA: Zhongguo Xiu Fu Chong Jian Wai

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