Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat.

Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat. Research Abstract Details 

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Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat. Abstract Text:

Shilei Zhang,Wenhua Yuan,

OBJECTIVE: To evaluate whether or not administration of vitamin B(6) (vitB(6)) has preventive effects on cleft palate formation. METHODS: On the 14, 15 day of gestation, the pregnant rats were treated with administration of vitB(6) (10 mg/kg weight im) before and simultaneously with dexamethason (DEX). Compared the palatal cleft incidence of their fetuses with those whose mother were given DEX only. RESULTS: Treatment with administration of vitB(6) before and simultaneously with DEX, the palatal cleft incidence of subject group fetuses (32.35%) was significantly less than that given DEX only (64.52%). The proportion of the palatal cleft type was also changed significantly. CONCLUSIONS: VitB(6) decrease both the incidence and the severity of cleft palate induced by DEX in rats, which indicates VitB(6) may have preventive effects on cleft palate formation.

Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat. Publishing Authors By Initials

S Zhang,W Yuan,

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Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqia

VOLUME: 37

Page Numbers: 272-4

Journal Abbreviation: Zhonghua Kou Qiang Yi Xue Za Z

ISSN: 1002-0098

DAY: 4

MONTH: Jul

YEAR: 2002

Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 8711066

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Grant and Affiliation Information for Experimental study on effects of vitamin B(6) on dexamethason-induced palatal cleft formation in the rat.

AFFILIATION: Center of Cleft Palate, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.

Country: China

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MEDLINETA: Zhonghua Kou Qiang Yi Xue Za Z

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