[Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin]

[Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin] Research Abstract Details 

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[Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin] Abstract Text:

Qing-liu Hu,Ying-jie Piao,Fei Zou,

OBJECTIVE: To evaluate the effect of conduits made of human hair keratin (HHK) in repairing injured peripheral nerve. METHODS: Twenty-five normal New Zealand rabbits were used in this study, which were divided into 3 groups including a control group (n=5) and 2 experiment groups. The tibial nerves of rabbits in the 2 experiments groups were transected to create a 10-mm gap, then were either routinely sutured (group II, n=10) or repaired by inserting both nerve stumps into the lumen of the conduit, followed by suturing the epineurium of the nerve stumps with HHK conduits using 9-0 nylon (group III, n=10). Electrophysiological, anatomic and histological examinations were performed at different time points after surgery. RESULTS: Noteworthy improvement in healing could be seen from electrophysiological results of group III, in which HHK conduits were partially degraded and embedded in white tissue, crisp and fragile. Large amount of infantile myelinated nerve fibers and schwann cells were observed under optical microscope to regenerate around HHK, which was partially degraded and absorbed, 92 d postoperatively. One year after the operation, the severed tibial nerves were perfectly repaired and HHK completely degraded. Transmission electron microscopy identified Schwann cell proliferation and myelinization around HHK 92 d after operation, but the delamination of the myelin was not manifest until observed with greater magnifications. There were nerve fibrils in the myelin, where organelles such as mitochondrion could be seen. CONCLUSION: As an ideal material for nerve injury repair, HHK conduits can guide tibial nerve elongation across a 10-mm gap.

[Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin] Publishing Authors By Initials

QL Hu,YJ Piao,F Zou,

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[Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Di 1 jun yi da xue xue bao = Academic journal of t

VOLUME: 22

Page Numbers: 784-7

Journal Abbreviation: Di Yi Jun Yi Da Xue Xue Bao

ISSN: 1000-2588

DAY: 25

MONTH: Sep

YEAR: 2002

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LANGUAGE: chi

NlmUniqueID: 9426110

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Grant and Affiliation Information for [Experimental study of repairing peripheral nerve damage with conduit made of human hair keratin]

AFFILIATION: Department of High Temperature Medicine, First Military Medical University, Guangzhou 510515, China. huqingliu@163.net

Country: China

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MEDLINETA: Di Yi Jun Yi Da Xue Xue Bao

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